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Bifidobacteria attenuate the development of metabolic disorders, with inter- and intra-species differences.

  • 2018
  • Food & Function 9(6)
    • G. Zhu
    • Fangli Ma
    • Gang Wang
    • Yuanyuan Wang
    • Jianxin Zhao
    • Hao Zhang
    • Wei Chen

Abstract

Host gut microbiota dysbiosis occurs for multiple reasons and is often accompanied by chronic inflammation induced by a high-fat-high-sucrose (HFHS) diet and related metabolic disorders. Intervention with probiotics is a novel strategy for amelioration of metabolic syndrome, which is believed to regulate the gut microbiota composition to some extent. We investigated the relationship amongst bifidobacteria treatment, HFHS diet-induced metabolic disorders and the gut microbiota composition. Seven strains of bifidobacteria from four species were individually administered to rats fed a HFHS diet for 12 weeks. Various bifidobacteria strains showed various effects on the recovery of metabolic disorders and gut microbiota dysbiosis, and these effects seemed to be inter- or intra-species specific. Bifidobacterium longum, B. adolescentis and B. bifidum seemed to affect the blood glucose balance, whilst two strains of B. breve showed extremely different effects in this area. However, only one strain of B. longum and the B. adolescentis displayed significant regulation of blood lipid levels. The protective effects of bifidobacteria on the pancreas were strongly correlated with those on blood glucose. Furthermore, the influence of bifidobacteria on gut microbiota dysbiosis also showed a potential relationship with symptoms of metabolic disorders. Of these seven strains, B. adolescentis Z25 displayed an outstanding ability to alleviate metabolic syndrome, including glucose and lipid metabolism disorders, tissue damage and gut microbiota dysbiosis. This strain, coupled with other prebiotics and probiotics, could be used as a potential treatment approach for metabolic syndrome induced by a HFHS diet.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium adolescentisEnhanced Pancreatic HealthBeneficial
Moderate
Bifidobacterium adolescentisImproved Blood Glucose RegulationBeneficial
Large
Bifidobacterium adolescentisReduced DysbiosisBeneficial
Moderate
Bifidobacterium adolescentisReduced Metabolic SyndromeBeneficial
Large
Bifidobacterium adolescentisRegulated Blood Lipid LevelsBeneficial
Moderate

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