Bifidobacterium animalis subsp. lactis as adjunct to non-surgical periodontal treatment in periodontitis: a randomized controlled clinical trial.
- 2023-01-25
- Clinical oral investigations 27(5)
- Hafize Öztürk Özener
- Leyla Kuru
- Tanju Kadir
- Bahar Kuru
- PubMed: 36697840
- DOI: 10.1007/s00784-023-04870-1
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Population
- 30 periodontitis patients
- Methods
- prospective randomized controlled clinical study; adjunctive to supra and subgingival instrumentation, test group consumed Bifidobacterium animalis subsp. lactis DN-173010 containing yogurt, control group consumed natural yogurt, once daily for 28 days
- Blinding
- Open-label
- Duration
- 28 days
- Funding
- Unclear
Objectives
The purpose of this study is to investigate the clinical and microbiological effects of Bifidobacterium animalis subsp. lactis DN-173010 containing yogurt as an adjunct to non-surgical periodontal treatment in periodontitis patients.Materials and methods
This is a prospective randomized controlled clinical study registered with NCT05408364 under clinical trial registration. Thirty periodontitis patients were divided into 2 groups at random. As adjunctive to supra and subgingival instrumentation, the test group consumed Bifidobacterium animalis subsp. lactis DN-173010 containing yogurt while the control group consumed natural yogurt, once daily for 28 days. The plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL) were recorded at baseline, 28th day, and 3rd month. Microbiological analysis was performed using culture method by obtaining subgingival plaque samples from 2 periodontal sites with 4≤PD≤6 mm at the same time points.Results
The inter-group comparisons of PI, GI, and BOP as well as the changes between the measurement time points were statistically significant in favor of the test group. There were no significant differences in terms of PD and CAL changes between the study groups at all times (∆baseline-28 days, ∆baseline-3 months) (p>0.05). The number of patients presenting subgingival Bifidobacterium species was significantly greater in the test group than the control group at the 28th day (p<0.05).Conclusions
The administration of probiotics has shown beneficial effects, albeit limited, on clinical and microbiological outcomes in the management of periodontitis patients.Clinical relevance
Daily consumption of probiotic yogurt may be supportive for supra and subgingival instrumentation.Research Insights
The inter-group comparisons of PI, GI, and BOP as well as the changes between the measurement time points were statistically significant in favor of the test group.
- Effect
- Beneficial
- Effect size
- Moderate
- Dose
- one 28-day course of yogurt (specific dose of CFU not stated)
There were no significant differences in terms of PD and CAL changes between the study groups at all times (∆baseline-28 days, ∆baseline-3 months) (p>0.05).
- Effect
- Neutral
- Effect size
- Small
- Dose
- one 28-day course of yogurt (specific dose of CFU not stated)
The inter-group comparisons of PI, GI, and BOP as well as the changes between the measurement time points were statistically significant in favor of the test group.
- Effect
- Beneficial
- Effect size
- Moderate
- Dose
- one 28-day course of yogurt (specific dose of CFU not stated)
The inter-group comparisons of PI, GI, and BOP as well as the changes between the measurement time points were statistically significant in favor of the test group.
- Effect
- Beneficial
- Effect size
- Moderate
- Dose
- one 28-day course of yogurt (specific dose of CFU not stated)
There were no significant differences in terms of PD and CAL changes between the study groups at all times (∆baseline-28 days, ∆baseline-3 months) (p>0.05).
- Effect
- Neutral
- Effect size
- Small
- Dose
- one 28-day course of yogurt (specific dose of CFU not stated)