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Bifidobacterium animalis subsp. lactis boosts neonatal immunity: unravelling systemic defences against Salmonella.

  • 2024
  • Food & Function 15(1)
    • Chunxiu Lin
    • Yugui Lin
    • Shunhe Wang
    • Jialiang Wang
    • Xuhua Mao
    • Yonghua Zhou
    • Hao Zhang
    • Wei Chen
    • Gang Wang

Abstract

Bifidobacterium animalis subsp. lactis may be a useful probiotic intervention for regulating neonatal intestinal immune responses and counteracting Salmonella infection. However, recent research has focused on intestinal immunity, leaving uncertainties regarding the central, peripheral, and neural immune responses in neonates. Therefore, this study investigated the role and mechanisms of B. animalis subsp. lactis in the systemic immune responses of neonatal rats following Salmonella infection. Through extremely early pretreatment with B. animalis subsp. lactis (6 hours postnatal), the neonatal rat gut microbiota was effectively reshaped, especially the Bifidobacterium community. In the rats pretreated with B. animalis subsp. lactis, Salmonella was less prevalent in the blood, liver, spleen, and intestines following infection. The intervention promoted T lymphocyte subset balance in the spleen and thymus and fostered neurodevelopment and neuroimmune balance in the brain. Furthermore, metabolic profiling showed a strong correlation between the metabolites in the serum and colon, supporting the view that B. animalis subsp. lactis pretreatment influences the systemic immune response by modifying the composition and metabolism of the gut microbiota. Overall, the results imply that B. animalis subsp. lactis pretreatment, through the coordinated regulation of colonic and serum metabolites, influences the systemic immune responses of neonatal rats against Salmonella infection.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium animalis subsp. lactisAltered Gut Microbiota CompositionBeneficial
Large
Bifidobacterium animalis subsp. lactisImproved T Lymphocyte Subset BalanceBeneficial
Moderate
Bifidobacterium animalis subsp. lactisInfluenced Systemic Immune ResponseBeneficial
Large
Bifidobacterium animalis subsp. lactisReduced Salmonella IncidenceBeneficial
Large

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