Bifidobacterium breve B-3 exerts metabolic syndrome-suppressing effects in the liver of diet-induced obese mice: a DNA microarray analysis.
- 2013-09-01
- Beneficial Microbes 4(3)
- S. Kondo
- A. Kamei
- J.‐Z. Xiao
- K. Iwatsuki
- K. Abe
- PubMed: 23666099
- DOI: 10.3920/BM2012.0019
Abstract
We previously reported that supplementation with Bifidobacterium breve B-3 reduced body weight gain and accumulation of visceral fat in a dose-dependent manner, and improved serum levels of total cholesterol, glucose and insulin in a mouse model of diet-induced obesity. In this study, we investigated the expression of genes in the liver using DNA microarray analysis and q-PCR to reveal the mechanism of these anti-obesity effects in this mouse model. Administration of B. breve B-3 led to regulated gene expression of pathways involved in lipid metabolism and response to stress. The results indicate that these regulations in the liver are related to the anti-metabolic syndrome effects of B. breve B-3.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bifidobacterium breve BR03 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Improved Serum Glucose Levels | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Improved Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Reduced Body Weight | Beneficial | Large |
| Bifidobacterium breve BR03 | Reduced Visceral Fat | Beneficial | Large |
| Bifidobacterium breve BR03 | Regulated Gene Expression Due to Stress | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Regulated Gene Expression in Lipid Metabolism | Beneficial | Moderate |