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Abstract

We previously reported that supplementation with Bifidobacterium breve B-3 reduced body weight gain and accumulation of visceral fat in a dose-dependent manner, and improved serum levels of total cholesterol, glucose and insulin in a mouse model of diet-induced obesity. In this study, we investigated the expression of genes in the liver using DNA microarray analysis and q-PCR to reveal the mechanism of these anti-obesity effects in this mouse model. Administration of B. breve B-3 led to regulated gene expression of pathways involved in lipid metabolism and response to stress. The results indicate that these regulations in the liver are related to the anti-metabolic syndrome effects of B. breve B-3.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium breve BR03Improved Insulin SensitivityBeneficial
Moderate
Bifidobacterium breve BR03Improved Serum Glucose LevelsBeneficial
Moderate
Bifidobacterium breve BR03Improved Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium breve BR03Reduced Body WeightBeneficial
Large
Bifidobacterium breve BR03Reduced Visceral FatBeneficial
Large
Bifidobacterium breve BR03Regulated Gene Expression Due to StressBeneficial
Moderate
Bifidobacterium breve BR03Regulated Gene Expression in Lipid MetabolismBeneficial
Moderate
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