Bifidobacterium breve CCFM1078 Alleviates Collagen-Induced Arthritis in Rats via Modulating the Gut Microbiota and Repairing the Intestinal Barrier Damage.
- 2022-11-15
- Journal of Agricultural and Food Chemistry 70(46)
- Bowen Li
- M. Ding
- Xiaoming Liu
- Jianxin Zhao
- R. Ross
- C. Stanton
- Bo Yang
- Wei Chen
- PubMed: 36377740
- DOI: 10.1021/acs.jafc.2c04602
Abstract
This study focused on the effects of Bifidobacterium breve CCFM1078 on the intestinal barrier and systemic inflammation of collagen-induced arthritis (CIA) rats. Female rats were divided into three groups with daily intragastric administration of either saline (control group and model group) or B. breve CCFM1078 (CCFM1078 group, 3 × 109cfu/rat per day) for 5 weeks. In the Model and CCFM1078 groups, arthritis was induced by subcutaneous collagen injection. We found that B. breve CCFM1078 can repair the intestinal barrier, reduce LPS translocation, regulate gut microbiota composition, and increase short-chain fatty acids in the intestine. Then, it can reduce pro-inflammatory cytokines release, adjust immune dysfunction, and inhibit TLR4-MyD88-dependent pathways and downstream inflammatory pathways to alleviate joint inflammation in CIA rats. These findings suggest that B. breve CCFM1078 may alleviate joint inflammation by adjusting the profile of gut microbiota and enhancing the intestinal barrier.
Keywords: Bifidobacterium breve; arthritis; gut microbiota; inflammatory; intestinal barrier.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bifidobacterium breve | Adjusted Immune Function | Beneficial | Moderate |
| Bifidobacterium breve | Improved Intestinal Barrier Function | Beneficial | Large |
| Bifidobacterium breve | Increased Short-Chain Fatty Acid Levels | Beneficial | Moderate |
| Bifidobacterium breve | Optimized Gut Microbiota Composition | Beneficial | Moderate |
| Bifidobacterium breve | Reduced Inflammatory Pathways | Beneficial | Moderate |
| Bifidobacterium breve | Reduced Joint Inflammation | Beneficial | Large |
| Bifidobacterium breve | Reduced LPS Translocation | Beneficial | Moderate |
| Bifidobacterium breve | Reduced Pro-Inflammatory Cytokines | Beneficial | Moderate |
| Bifidobacterium breve Bb-03 | Improved Gut Microbiome Composition | Beneficial | Large |
| Bifidobacterium breve Bb-03 | Improved Intestinal Barrier Function | Beneficial | Large |
| Bifidobacterium breve Bb-03 | Reduced Inflammation Levels | Beneficial | Large |
| Bifidobacterium breve Bb-03 | Reduced Joint Inflammation | Beneficial | Large |
| Bifidobacterium breve BBr60 | Modulated Gut Microbiota Composition | Beneficial | Moderate |
| Bifidobacterium breve BBr60 | Reduced Inflammation Levels | Beneficial | Large |
| Bifidobacterium breve BBr60 | Reduced Joint Inflammation | Beneficial | Large |
| Bifidobacterium breve BBr60 | Reduced LPS Translocation | Beneficial | Moderate |
| Bifidobacterium breve Bbr8 | Improved Intestinal Barrier Function | Beneficial | Large |
| Bifidobacterium breve Bbr8 | Reduced Inflammation Levels | Beneficial | Large |
| Bifidobacterium breve Bbr8 | Reduced Joint Inflammation | Beneficial | Large |
| Bifidobacterium breve BR-03 | Improved Intestinal Barrier Function | Beneficial | Large |
| Bifidobacterium breve BR-03 | Modulated Gut Microbiota Composition | Beneficial | Moderate |
| Bifidobacterium breve BR-03 | Reduced Inflammation Levels | Beneficial | Large |
| Bifidobacterium breve BR-03 | Reduced Joint Inflammation | Beneficial | Large |
| Bifidobacterium breve BR03 | Adjusted Immune Function | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Improved Intestinal Mucosal Barrier Function | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Increased Short-Chain Fatty Acid Levels | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Optimized Gut Microbiota Composition | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Reduced Inflammatory Pathways | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Reduced LPS Translocation | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Reduced Pro-inflammatory Cytokine Levels | Beneficial | Large |
| Bifidobacterium breve HA-129 | Improved Intestinal Barrier Function | Beneficial | Large |
| Bifidobacterium breve HA-129 | Optimized Gut Microbiota Composition | Beneficial | Moderate |
| Bifidobacterium breve HA-129 | Reduced Joint Inflammation | Beneficial | Large |
| Bifidobacterium breve HA-129 | Reduced Pro-inflammatory Cytokine Levels | Beneficial | Large |
| Bifidobacterium breve IDCC 4401 | Improved Intestinal Barrier Function | Beneficial | Large |
| Bifidobacterium breve IDCC 4401 | Reduced Inflammation Levels | Beneficial | Large |
| Bifidobacterium breve M-16V | Improved Intestinal Barrier Function | Beneficial | Large |
| Bifidobacterium breve M-16V | Reduced Joint Inflammation | Beneficial | Large |
| Bifidobacterium breve M-16V | Reduced Pro-inflammatory Cytokine Levels | Beneficial | Large |
| Bifidobacterium breve MAK40B22B | Improved Intestinal Barrier Function | Beneficial | Large |
| Bifidobacterium breve MAK40B22B | Increased Short-Chain Fatty Acid Levels | Beneficial | Moderate |
| Bifidobacterium breve MAK40B22B | Optimized Gut Microbiota Composition | Beneficial | Moderate |
| Bifidobacterium breve MAK40B22B | Reduced Inflammation Levels | Beneficial | Large |
| Bifidobacterium breve MAK40B22B | Reduced Joint Inflammation | Beneficial | Large |
| Bifidobacterium breve MAK40B22B | Reduced LPS Translocation | Beneficial | Moderate |
| Bifidobacterium breve R0070 | Improved Intestinal Barrier Function | Beneficial | Large |
| Bifidobacterium breve R0070 | Reduced Pro-inflammatory Cytokine Release | Beneficial | Large |
| Bifidobacterium breve R0070 | Regulated Gut Microbiota | Beneficial | Moderate |
| Bifidobacterium breve Rosell-70 | Reduced Joint Inflammation | Beneficial | Large |
| Bifidobacterium breve SD5206 | Adjusted Immune Function | Beneficial | Moderate |
| Bifidobacterium breve SD5206 | Improved Intestinal Barrier Function | Beneficial | Large |
| Bifidobacterium breve SD5206 | Increased Short-Chain Fatty Acid Levels | Beneficial | Moderate |
| Bifidobacterium breve SD5206 | Inhibited TLR4-MyD88-Dependent Pathways | Beneficial | Moderate |
| Bifidobacterium breve SD5206 | Optimized Gut Microbiota Composition | Beneficial | Moderate |
| Bifidobacterium breve SD5206 | Reduced Pro-inflammatory Cytokine Levels | Beneficial | Large |
| Bifidobacterium breve UABbr-11 | Improved Intestinal Barrier Function | Beneficial | Large |
| Bifidobacterium breve UABbr-11 | Increased Short Chain Fatty Acids | Beneficial | Moderate |
| Bifidobacterium breve UABbr-11 | Regulated Gut Microbiota | Beneficial | Moderate |
| Bifidobacterium breve VPro 52 | Improved Intestinal Barrier Function | Beneficial | Large |
| Bifidobacterium breve VPro 52 | Optimized Gut Microbiota Composition | Beneficial | Moderate |
| Bifidobacterium breve VPro 52 | Reduced LPS Translocation | Beneficial | Moderate |
| Bifidobacterium breve VPro 52 | Reduced Pro-Inflammatory Cytokines | Beneficial | Moderate |