Skip to main content

Bifidobacterium breve CCFM1078 Alleviates Collagen-Induced Arthritis in Rats via Modulating the Gut Microbiota and Repairing the Intestinal Barrier Damage.

  • 2022-11-15
  • Journal of Agricultural and Food Chemistry 70(46)
    • Bowen Li
    • M. Ding
    • Xiaoming Liu
    • Jianxin Zhao
    • R. Ross
    • C. Stanton
    • Bo Yang
    • Wei Chen

Abstract

This study focused on the effects of Bifidobacterium breve CCFM1078 on the intestinal barrier and systemic inflammation of collagen-induced arthritis (CIA) rats. Female rats were divided into three groups with daily intragastric administration of either saline (control group and model group) or B. breve CCFM1078 (CCFM1078 group, 3 × 109cfu/rat per day) for 5 weeks. In the Model and CCFM1078 groups, arthritis was induced by subcutaneous collagen injection. We found that B. breve CCFM1078 can repair the intestinal barrier, reduce LPS translocation, regulate gut microbiota composition, and increase short-chain fatty acids in the intestine. Then, it can reduce pro-inflammatory cytokines release, adjust immune dysfunction, and inhibit TLR4-MyD88-dependent pathways and downstream inflammatory pathways to alleviate joint inflammation in CIA rats. These findings suggest that B. breve CCFM1078 may alleviate joint inflammation by adjusting the profile of gut microbiota and enhancing the intestinal barrier.

Keywords: Bifidobacterium breve; arthritis; gut microbiota; inflammatory; intestinal barrier.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium breveAdjusted Immune FunctionBeneficial
Moderate
Bifidobacterium breveImproved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium breveIncreased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Bifidobacterium breveOptimized Gut Microbiota CompositionBeneficial
Moderate
Bifidobacterium breveReduced Inflammatory PathwaysBeneficial
Moderate
Bifidobacterium breveReduced Joint InflammationBeneficial
Large
Bifidobacterium breveReduced LPS TranslocationBeneficial
Moderate
Bifidobacterium breveReduced Pro-Inflammatory CytokinesBeneficial
Moderate
Bifidobacterium breve Bb-03Improved Gut Microbiome CompositionBeneficial
Large
Bifidobacterium breve Bb-03Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium breve Bb-03Reduced Inflammation LevelsBeneficial
Large
Bifidobacterium breve Bb-03Reduced Joint InflammationBeneficial
Large
Bifidobacterium breve BBr60Modulated Gut Microbiota CompositionBeneficial
Moderate
Bifidobacterium breve BBr60Reduced Inflammation LevelsBeneficial
Large
Bifidobacterium breve BBr60Reduced Joint InflammationBeneficial
Large
Bifidobacterium breve BBr60Reduced LPS TranslocationBeneficial
Moderate
Bifidobacterium breve Bbr8Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium breve Bbr8Reduced Inflammation LevelsBeneficial
Large
Bifidobacterium breve Bbr8Reduced Joint InflammationBeneficial
Large
Bifidobacterium breve BR03Adjusted Immune FunctionBeneficial
Moderate
Bifidobacterium breve BR03Improved Intestinal Mucosal Barrier FunctionBeneficial
Moderate
Bifidobacterium breve BR03Increased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Bifidobacterium breve BR03Optimized Gut Microbiota CompositionBeneficial
Moderate
Bifidobacterium breve BR03Reduced Inflammatory PathwaysBeneficial
Moderate
Bifidobacterium breve BR03Reduced LPS TranslocationBeneficial
Moderate
Bifidobacterium breve BR03Reduced Pro-inflammatory Cytokine LevelsBeneficial
Large
Bifidobacterium breve BR-03Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium breve BR-03Modulated Gut Microbiota CompositionBeneficial
Moderate
Bifidobacterium breve BR-03Reduced Inflammation LevelsBeneficial
Large
Bifidobacterium breve BR-03Reduced Joint InflammationBeneficial
Large
Bifidobacterium breve HA-129Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium breve HA-129Optimized Gut Microbiota CompositionBeneficial
Moderate
Bifidobacterium breve HA-129Reduced Joint InflammationBeneficial
Large
Bifidobacterium breve HA-129Reduced Pro-inflammatory Cytokine LevelsBeneficial
Large
Bifidobacterium breve IDCC 4401Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium breve IDCC 4401Reduced Inflammation LevelsBeneficial
Large
Bifidobacterium breve M-16VImproved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium breve M-16VReduced Joint InflammationBeneficial
Large
Bifidobacterium breve M-16VReduced Pro-inflammatory Cytokine LevelsBeneficial
Large
Bifidobacterium breve MAK40B22BImproved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium breve MAK40B22BIncreased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Bifidobacterium breve MAK40B22BOptimized Gut Microbiota CompositionBeneficial
Moderate
Bifidobacterium breve MAK40B22BReduced Inflammation LevelsBeneficial
Large
Bifidobacterium breve MAK40B22BReduced Joint InflammationBeneficial
Large
Bifidobacterium breve MAK40B22BReduced LPS TranslocationBeneficial
Moderate
Bifidobacterium breve R0070Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium breve R0070Reduced Pro-inflammatory Cytokine ReleaseBeneficial
Large
Bifidobacterium breve R0070Regulated Gut MicrobiotaBeneficial
Moderate
Bifidobacterium breve Rosell-70Reduced Joint InflammationBeneficial
Large
Bifidobacterium breve SD5206Adjusted Immune FunctionBeneficial
Moderate
Bifidobacterium breve SD5206Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium breve SD5206Increased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Bifidobacterium breve SD5206Inhibited TLR4-MyD88-Dependent PathwaysBeneficial
Moderate
Bifidobacterium breve SD5206Optimized Gut Microbiota CompositionBeneficial
Moderate
Bifidobacterium breve SD5206Reduced Pro-inflammatory Cytokine LevelsBeneficial
Large
Bifidobacterium breve UABbr-11Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium breve UABbr-11Increased Short Chain Fatty AcidsBeneficial
Moderate
Bifidobacterium breve UABbr-11Regulated Gut MicrobiotaBeneficial
Moderate
Bifidobacterium breve VPro 52Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium breve VPro 52Optimized Gut Microbiota CompositionBeneficial
Moderate
Bifidobacterium breve VPro 52Reduced LPS TranslocationBeneficial
Moderate
Bifidobacterium breve VPro 52Reduced Pro-Inflammatory CytokinesBeneficial
Moderate

Pillser helps you make informed health decisions by providing comprehensive, unbiased information about supplements. This includes detailed research on supplement ingredients, their benefits, potential risks, and their overall efficacy. You can contribute by sharing your feedback and suggestions.

Send us an email at support@pillser.com.