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Bifidobacterium infantis has a beneficial effect on 5-fluorouracil-induced intestinal mucositis in rats.

  • 2015-01-01
  • Beneficial Microbes 6(1)
    • Kai-Tao Yuan
    • Honglan Yu
    • W. Feng
    • P. Chong
    • T. Yang
    • Conglong Xue
    • M. Yu
    • Houyin Shi


Intestinal mucositis is a common toxic side effect in cancer patients receiving high-dose chemotherapy. This study aimed to evaluate the beneficial effects of Bifidobacterium infantis in a rat model of intestinal mucositis induced by 5-fluorouracil (5-FU). Thirty male Sprague-Dawley rats were divided into three groups: control, 5-FU, and 5-FU + B. infantis. A single intraperitoneal injection of 5-FU (150 mg/kg) was used to induce intestinal mucositis. B. infantis (1×109 cfu) was administered for 11 days, starting from 7 days before 5-FU injection. Intestinal mucositis was evaluated based on body weight, villus height, immunohistological expression of proliferating cell nuclear antigen (PCNA) and nuclear factor kappa beta (NF-κB), levels of the pro-inflammatory factors interleukin 1 beta and tumour necrosis factor alpha, and myeloperoxidase (MPO) concentration. The results showed that the 5-FU + B. infantis group demonstrated a higher body weight and villus height, increased expression of PCNA, reduced expression of NF-κB and pro-inflammatory factors, and lower MPO concentration compared to the 5-FU group. These data suggest that probiotic B. infantis is effective in reducing chemotherapy-induced intestinal mucositis in rats.

Keywords: 5-fluorouracil; Bifidobacterium infantis; chemotherapy; mucositis; probiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium infantisIncreased Body WeightBeneficial
Bifidobacterium infantisIncreased Proliferating Cell Nuclear Antigen (PCNA) ExpressionBeneficial
Bifidobacterium infantisIncreased Villus HeightBeneficial
Bifidobacterium infantisReduced Myeloperoxidase (MPO) ConcentrationBeneficial
Bifidobacterium infantisReduced NF-κB ExpressionBeneficial
Bifidobacterium infantisReduced Pro-Inflammatory MarkersBeneficial

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