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Bifidobacterium infantis has a beneficial effect on 5-fluorouracil-induced intestinal mucositis in rats.

  • 2015-01-01
  • Beneficial Microbes 6(1)
    • Kai-Tao Yuan
    • Honglan Yu
    • W. Feng
    • P. Chong
    • T. Yang
    • Conglong Xue
    • M. Yu
    • Houyin Shi

Abstract

Intestinal mucositis is a common toxic side effect in cancer patients receiving high-dose chemotherapy. This study aimed to evaluate the beneficial effects of Bifidobacterium infantis in a rat model of intestinal mucositis induced by 5-fluorouracil (5-FU). Thirty male Sprague-Dawley rats were divided into three groups: control, 5-FU, and 5-FU + B. infantis. A single intraperitoneal injection of 5-FU (150 mg/kg) was used to induce intestinal mucositis. B. infantis (1×109 cfu) was administered for 11 days, starting from 7 days before 5-FU injection. Intestinal mucositis was evaluated based on body weight, villus height, immunohistological expression of proliferating cell nuclear antigen (PCNA) and nuclear factor kappa beta (NF-κB), levels of the pro-inflammatory factors interleukin 1 beta and tumour necrosis factor alpha, and myeloperoxidase (MPO) concentration. The results showed that the 5-FU + B. infantis group demonstrated a higher body weight and villus height, increased expression of PCNA, reduced expression of NF-κB and pro-inflammatory factors, and lower MPO concentration compared to the 5-FU group. These data suggest that probiotic B. infantis is effective in reducing chemotherapy-induced intestinal mucositis in rats.

Keywords: 5-fluorouracil; Bifidobacterium infantis; chemotherapy; mucositis; probiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium infantisIncreased Body WeightBeneficial
Moderate
Bifidobacterium infantisIncreased Proliferating Cell Nuclear Antigen (PCNA) ExpressionBeneficial
Large
Bifidobacterium infantisIncreased Villus HeightBeneficial
Moderate
Bifidobacterium infantisReduced Myeloperoxidase (MPO) ConcentrationBeneficial
Moderate
Bifidobacterium infantisReduced NF-κB ExpressionBeneficial
Moderate
Bifidobacterium infantisReduced Pro-Inflammatory MarkersBeneficial
Large

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