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Bifidobacterium longum BL-10 with Antioxidant Capacity Ameliorates Lipopolysaccharide-Induced Acute Liver Injury in Mice by the Nuclear Factor-κB Pathway.

  • 2022-07-07
  • Journal of Agricultural and Food Chemistry 70(28)
    • Jiahuan Dong
    • Lijun Ping
    • Y. Meng
    • Kangyong Zhang
    • Hongwei Tang
    • Deyu Liu
    • Bailiang Li
    • G. Huo


Bifidobacterium longum is frequently utilized and has broad prospects for preventing liver injury. The current research assessed the antioxidant capacity of B. longum BL-10 and probed its mechanism for ameliorating lipopolysaccharide (LPS)-induced acute liver injury (ALI). B. longum BL-10-encoded 15 antioxidant genes showed strong reducing power activity and scavenging activity of DPPH, hydroxyl radicals, and superoxide anions. The intragastric administration of B. longum BL-10 resulting in a marked reduction in liver function indicators (alanine aminotransferase, aspartate aminotransferase, total bilirubin, and total bile acid) and proinflammatory cytokines (TNF-α, IFN-γ, and IL-6) was indicative of ALI recovery. Following 16s RNA analysis, B. longum BL-10 significantly altered the richness of genera, as for the Escherichia-Shigella, Lachnospiraceae_NK4A136_group, and Clostridia_UCG-014, dramatically contributing to the formation of acetic acid and butyric acid. Meanwhile, their metabolites regulated the TLR4/NF-κB signaling pathways to alleviate hepatic injury symptoms. Overall, all the results demonstrated that B. longum BL-10 had excellent efficiency in preventing LPS-induced ALI.

Keywords: Bifidobacterium longum; LPS-induced liver injury; TLR4/NF-κB signaling pathway; genomic analysis; gut−microbiota−liver axis.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium longum B1-05Altered Gut Microbiota RichnessBeneficial
Bifidobacterium longum B1-05Improved Regulation of TLR4/NF-κB Signaling PathwaysBeneficial
Bifidobacterium longum BL03Improved Gut Microbiota CompositionBeneficial
Bifidobacterium longum BL03Improved Regulation of TLR4/NF-κB Signaling PathwaysBeneficial
Bifidobacterium longum BL03Reduced Liver Function IndicatorsBeneficial
Bifidobacterium longum BL03Reduced Pro-Inflammatory CytokinesBeneficial
Bifidobacterium longum MAK34B12LImproved Acute Liver InjuryBeneficial
Bifidobacterium longum MAK34B12LImproved Antioxidant CapacityBeneficial

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