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Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human

  • 2021-01
  • EBioMedicine 63
    • H. Schellekens
    • C. Torres-Fuentes
    • M. van de Wouw
    • C. Long-Smith
    • A. Mitchell
    • C. Strain
    • K. Berding
    • T. Bastiaanssen
    • K. Rea
    • A. Golubeva
    • S. Arboleya
    • Mathieu Verpaalen
    • M. Pusceddu
    • A. Murphy
    • F. Fouhy
    • K. Murphy
    • P. Ross
    • Bernard L. Roy
    • C. Stanton
    • T. Dinan
    • J. Cryan

Abstract

Background: The human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B. longum APC1472 supplementation reduces body-mass index (BMI) in healthy overweight/obese individuals as the primary outcome. B. longum APC1472 effects on waist-to-hip ratio (W/H ratio) and on obesity-associated plasma biomarkers were analysed as secondary outcomes.

Methods: B. longum APC1472 was administered to HFD-fed C57BL/6 mice in drinking water for 16 weeks. In the human intervention trial, participants received B. longum APC1472 or placebo supplementation for 12 weeks, during which primary and secondary outcomes were measured at the beginning and end of the intervention.

Findings: B. longum APC1472 supplementation was associated with decreased bodyweight, fat depots accumulation and increased glucose tolerance in HFD-fed mice. While, in healthy overweight/obese adults, the supplementation of B. longum APC1472 strain did not change primary outcomes of BMI (0.03, 95% CI [-0.4, 0.3]) or W/H ratio (0.003, 95% CI [-0.01, 0.01]), a positive effect on the secondary outcome of fasting blood glucose levels was found (-0.299, 95% CI [-0.44, -0.09]).

Interpretation: This study shows a positive translational effect of B. longum APC1472 on fasting blood glucose from a preclinical mouse model of obesity to a human intervention study in otherwise healthy overweight and obese individuals. This highlights the promising potential of B. longum APC1472 to be developed as a valuable supplement in reducing specific markers of obesity.

Funding: This research was funded in part by Science Foundation Ireland in the form of a Research Centre grant (SFI/12/RC/2273) to APC Microbiome Ireland and by a research grant from Cremo S.A.

Keywords: Bifidobacterium longum; Cortisol; Fasting blood glucose; Ghrelin; Gut microbiota; Obesity; Probiotic; Translational.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium lactis/longumImproved Glucose ToleranceBeneficial
Moderate
Bifidobacterium lactis/longumReduced Fasting Blood Sugar LevelsBeneficial
Moderate
Bifidobacterium lactis/longumStable Body-Mass Index (BMI)Neutral
Small
Bifidobacterium lactis/longumUnchanged Waist-to-Hip RatioNeutral
Small
Bifidobacterium longumImproved Glucose ToleranceBeneficial
Moderate
Bifidobacterium longumReduced Body WeightBeneficial
Moderate
Bifidobacterium longumReduced Fasting Blood Glucose LevelsBeneficial
Moderate
Bifidobacterium longumStable Body-Mass Index (BMI)Neutral
Small
Bifidobacterium longumUnchanged Waist-to-Hip RatioNeutral
Small
Bifidobacterium longum B1-05Improved Glucose ToleranceBeneficial
Moderate
Bifidobacterium longum B1-05Reduced Body WeightBeneficial
Moderate
Bifidobacterium longum B1-05Reduced Serum Glucose LevelsBeneficial
Moderate
Bifidobacterium longum BI-05Improved Blood Glucose LevelsBeneficial
Moderate
Bifidobacterium longum BI-05Improved Glucose ToleranceBeneficial
Moderate
Bifidobacterium longum BI-05Reduced Body WeightBeneficial
Moderate
Bifidobacterium longum BI-05Reduced Hepatic Fat AccumulationBeneficial
Moderate
Bifidobacterium longum BL03Reduced Serum Glucose LevelsBeneficial
Moderate
Bifidobacterium longum HA-135Improved Glucose ToleranceBeneficial
Moderate
Bifidobacterium longum HA-135Reduced Body WeightBeneficial
Moderate
Bifidobacterium longum HA-135Reduced Serum Glucose LevelsBeneficial
Moderate
Bifidobacterium longum iVE-15Improved Glucose ToleranceBeneficial
Moderate
Bifidobacterium longum KABP-042Reduced Fasting Blood Glucose LevelsBeneficial
Moderate
Bifidobacterium longum MAK34B12LImproved Glucose ToleranceBeneficial
Moderate
Bifidobacterium longum MAK34B12LReduced Body WeightBeneficial
Moderate
Bifidobacterium longum MAK34B12LReduced Fasting Blood Sugar LevelsBeneficial
Moderate
Bifidobacterium longum MM-2Reduced Fasting Blood Glucose LevelsBeneficial
Moderate
Bifidobacterium longum Rosell-175Improved Glucose ToleranceBeneficial
Moderate
Bifidobacterium longum Rosell-175Reduced Body WeightBeneficial
Moderate
Bifidobacterium longum Rosell-175Reduced Hepatic Fat AccumulationBeneficial
Moderate
Bifidobacterium longum Rosell-175Reduced Serum Glucose LevelsBeneficial
Moderate
Bifidobacterium longum Rosell-175 MEReduced Serum Glucose LevelsBeneficial
Moderate
Bifidobacterium longum SD-5588Improved Glucose ToleranceBeneficial
Moderate
Bifidobacterium longum SD-5588Reduced Body WeightBeneficial
Moderate
Bifidobacterium longum SD-5588Reduced Serum Glucose LevelsBeneficial
Moderate
Bifidobacterium longum SP54Change in Waist-to-Hip RatioNeutral
Small
Bifidobacterium longum SP54Improved Glucose ToleranceBeneficial
Moderate
Bifidobacterium longum SP54Reduced Body Mass IndexNeutral
Small
Bifidobacterium longum SP54Reduced Serum Glucose LevelsBeneficial
Moderate
Bifidobacterium longum subsp. longumImproved Glucose ToleranceBeneficial
Moderate
Bifidobacterium longum subsp. longumImproved Waist-to-Hip RatioNeutral
Small
Bifidobacterium longum subsp. longumReduced Body Mass IndexNeutral
Small
Bifidobacterium longum subsp. longumReduced Body WeightBeneficial
Moderate
Bifidobacterium longum subsp. longumReduced Fat Depots AccumulationBeneficial
Large
Bifidobacterium longum subsp. longumReduced Serum Glucose LevelsBeneficial
Moderate
Bifidobacterium longum subsp. longum 35624Reduced Serum Glucose LevelsBeneficial
Moderate
Bifidobacterium longum subsp. longum UABI-14Improved Glucose ToleranceBeneficial
Moderate
Bifidobacterium longum subsp. longum UABI-14Reduced Fasting Blood Sugar LevelsBeneficial
Moderate
Bifidobacterium longum UABI-14Improved Glucose ToleranceBeneficial
Moderate
Bifidobacterium longum UABI-14Reduced Body WeightBeneficial
Moderate
Bifidobacterium longum UABI-14Reduced Serum Glucose LevelsBeneficial
Moderate
Bifidobacterium longum UABl-14Reduced Fasting Blood Glucose LevelsBeneficial
Moderate
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