Bifidobacterium longum subsp infantis CECT7210-supplemented formula reduces diarrhea in healthy infants: a randomized controlled trial
- 2018-05-02
- Pediatric Research 83(6)
- J. Escribano
- N. Ferré
- M. Gispert-Llauradó
- V. Luque
- C. Rubio-Torrents
- M. Zaragoza-Jordana
- I. Polanco
- F. Codoñer
- E. Chenoll
- M. Morera
- J. A. Moreno-Muñoz
- M. Rivero
- R. Closa-Monasterolo
- PubMed: 29538368
- DOI: 10.1038/pr.2018.34
Abstract
BackgroundIntestinal microbiota of breast-fed infants is plenty of beneficial bifidobacteria. We aimed to determine whether an infant formula supplemented with probiotic Bifidobacterium longum subsp. infantis CECT7210 (B. infantis IM1) is effective at reducing diarrhea incidence in healthy term infants.MethodsDouble-blinded, randomized, multicenter, controlled clinical trial, where formula-fed infants (<3 months) received an infant formula supplemented (Probiotic) or not (Control) with 107 cfu/g of B. infantis IM1 over 12 weeks. Diarrheas, growth, digestive symptoms, stool bifidobacteria, and microbiota were assessed.ResultsIn all, 97 (Control) and 93 (Probiotic) infants were randomized, and 78 (Control) and 73 (Probiotic) completed the 12 week-follow-up. In the overall study period, a median of 0.29±1.07 and 0.05±0.28 diarrhea events/infant was observed in the Control and Probiotic groups, respectively (P=0.059). This trend to less diarrhea episodes in the Probiotic group reached statistical significance at 8 weeks (0.12±0.47 vs. 0.0±0.0 events/infant, P=0.047). Constipation incidence was higher (odds ratio (OR) 2.67 (1.09-6.50)) and stool frequency lower (2.0±1.0 vs. 2.6±1.3 stools/day, P=0.038) in the Control group after 4 weeks. No differences were found at other time points nor in other digestive symptoms, growth, or formula intake.ConclusionA B. infantis IM1-supplemented infant formula may reduce diarrhea episodes, being safe, well tolerated, and associated with lower constipation prevalence.
Research Insights
Supplement | Health Outcome | Effect Type | Effect Size |
---|---|---|---|
Bifidobacterium infantis | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium infantis | Reduced Incidence of Constipation | Beneficial | Moderate |
Bifidobacterium infantis Bi-26 | Increased Constipation Risk | Harmful | Moderate |
Bifidobacterium infantis Bi-26 | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium infantis BI02 | Increased Constipation Risk | Harmful | Moderate |
Bifidobacterium infantis BI02 | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium infantis HA-116 | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium infantis HA-116 | Reduced Incidence of Constipation | Beneficial | Moderate |
Bifidobacterium infantis M-63 | Increased Constipation Risk | Harmful | Moderate |
Bifidobacterium infantis M-63 | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium infantis MAK22B041 | Increased Constipation Risk | Harmful | Moderate |
Bifidobacterium infantis MAK22B041 | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium infantis MAK22B04I | Increased Constipation Risk | Harmful | Moderate |
Bifidobacterium infantis MAK22B04I | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium infantis SD-6720 | No Impact on Digestive Symptoms, Growth, or Formula Intake | Neutral | Small |
Bifidobacterium infantis SD-6720 | Reduced Constipation Prevalence | Beneficial | Moderate |
Bifidobacterium infantis SD-6720 | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium infantis VPro 53 | Increased Constipation Risk | Harmful | Moderate |
Bifidobacterium infantis VPro 53 | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium infantis VPro 53 | Reduced Stool Frequency | Neutral | Small |
Bifidobacterium longum B1-05 | Increased Constipation Risk | Harmful | Moderate |
Bifidobacterium longum B1-05 | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium longum BI-05 | Increased Constipation Risk | Harmful | Moderate |
Bifidobacterium longum BI-05 | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium longum BI-05 | Reduced Incidence of Constipation | Beneficial | Moderate |
Bifidobacterium longum BL03 | Increased Constipation Risk | Harmful | Moderate |
Bifidobacterium longum BL03 | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium longum subsp. infantis | Increased Constipation Risk | Harmful | Moderate |
Bifidobacterium longum subsp. infantis | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium longum subsp. infantis | Reduced Incidence of Constipation | Beneficial | Moderate |
Bifidobacterium longum subsp. infantis M-63 | Increased Constipation Risk | Harmful | Moderate |
Bifidobacterium longum subsp. infantis M-63 | No Significant Change in Gastrointestinal Symptoms | Neutral | Small |
Bifidobacterium longum subsp. infantis M-63 | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium longum subsp. longum | Increased Constipation Risk | Harmful | Moderate |
Bifidobacterium longum subsp. longum | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium longum subsp. longum | Reduced Stool Frequency | Neutral | Small |
Bifidobacterium longum subsp. longum UABI-14 | Increased Constipation Risk | Harmful | Moderate |
Bifidobacterium longum subsp. longum UABI-14 | Reduced Diarrhea Incidence | Beneficial | Moderate |
Bifidobacterium longum subsp. longum UABI-14 | Reduced Stool Frequency | Neutral | Small |