Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial
- 2022-12-21
- Nutrients 15(1)
- H. Sung
- S. Youn
- Yong Choi
- S. Eun
- S. Shin
- PubMed: 36615686
- DOI: 10.3390/nu15010028
Abstract
This double-blind, randomized clinical trial aimed to evaluate the efficacy and safety of Bifidobacterium breve B-3 (BB-3) for reducing body fat. Healthy individuals were randomized into the BB-3 or placebo group (1:1). Dual-energy X-ray absorptiometry was used to evaluate body fat reduction objectively. In the BB-3 group, body weight was lower than before BB-3 ingestion. Regarding waist circumference, hip circumference, and waist/hip circumference ratio, waist circumference and hip circumference were lower in the BB-3 group than in the placebo group at 12 weeks; the waist/hip circumference ratio was found to decrease at each visit in the BB-3 group, although there was no significant difference in the amount of change after 12 weeks. BB-3 did not cause any severe adverse reactions. Body fat was significantly lower in the BB-3 group than in the placebo group. In conclusion, ingesting BB-3 significantly reduces body weight, waist circumference, and hip circumference. Thus, BB-3 is safe and effective for reducing body fat.
Keywords: Bifidobacterium breve B-3; nutritional supplement; obesity; placebo-controlled study; randomized trial.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bifidobacterium breve | Reduced Body Fat | Beneficial | Large |
| Bifidobacterium breve | Reduced Body Weight | Beneficial | Moderate |
| Bifidobacterium breve | Reduced Hip Circumference | Beneficial | Moderate |
| Bifidobacterium breve | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium breve | Reduced Waist-to-Hip Ratio | Beneficial | Small |
| Bifidobacterium breve Bb-03 | Reduced Body Fat | Beneficial | Large |
| Bifidobacterium breve Bb-03 | Reduced Body Weight | Beneficial | Moderate |
| Bifidobacterium breve Bb-03 | Reduced Hip Circumference | Beneficial | Moderate |
| Bifidobacterium breve Bb-03 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium breve Bb-03 | Reduced Waist-to-Hip Ratio | Beneficial | Small |
| Bifidobacterium breve Bb-18 | Reduced Body Fat | Beneficial | Large |
| Bifidobacterium breve Bb-18 | Reduced Body Weight | Beneficial | Moderate |
| Bifidobacterium breve Bb-18 | Reduced Hip Circumference | Beneficial | Moderate |
| Bifidobacterium breve Bb-18 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium breve Bb-18 | Reduced Waist-to-Hip Ratio | Beneficial | Small |
| Bifidobacterium breve BBr60 | Absence of Severe Adverse Reactions | Neutral | Small |
| Bifidobacterium breve Bbr8 | Reduced Body Fat | Beneficial | Large |
| Bifidobacterium breve Bbr8 | Reduced Hip Circumference | Beneficial | Moderate |
| Bifidobacterium breve Bbr8 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium breve BR-03 | Reduced Body Fat | Beneficial | Large |
| Bifidobacterium breve BR-03 | Reduced Body Weight | Beneficial | Moderate |
| Bifidobacterium breve BR-03 | Reduced Hip Circumference | Beneficial | Moderate |
| Bifidobacterium breve BR-03 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Reduced Body Fat | Beneficial | Large |
| Bifidobacterium breve BR03 | Reduced Body Weight | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Reduced Hip Circumference | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium breve MAK40B22B | Reduced Body Fat | Beneficial | Large |
| Bifidobacterium breve MAK40B22B | Reduced Body Weight | Beneficial | Moderate |
| Bifidobacterium breve MAK40B22B | Reduced Hip Circumference | Beneficial | Moderate |
| Bifidobacterium breve MAK40B22B | Reduced Waist Circumference | Beneficial | Moderate |