- 2023-01-26
- Molecular nutrition & food research 67(4)
- Wenting Wan
- Xianchen Jiang
- Ruifang Zhao
- Fenfen Cai
- Fan Wu
- Yunqi Hu
- Xiaoqin Zhou
- Zhipeng Liu
- Yujuan Shan
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Sample size
- n = 42
- Population
- subjects with T2DM
- Methods
- randomized controlled trial, 100 g day⁻¹ GBR (GBR group, n=42) or equal staple food (Control group, n=25) for 3 months
- Duration
- 3 months
Scope
Adequate intake of whole grain foods is beneficial to type 2 diabetes mellitus (T2DM). Whether the preventive effects are related with metabolism of branched-chain amino acids (BCAAs) is unclear. The study aims to evaluate the effects of germinated brown rice (GBR) intervention on BCAAs metabolism in T2DM patients.Methods and results
In this randomized controlled trial, subjects with T2DM are instructed to consume 100 g day-1 GBR (GBR group, n=42) or equal staple food (Control group, n=25) for 3 months. Food frequency questionnaires (FFQ) and serum samples are collected before and after the intervention. In the GBR group, fasting blood glucose (FBG), fasting insulin (FINS), and serum BCAAs are decreased, and islet function is improved (p<0.05). Logistic regression analysis showed that FBG (odds ratios 95% confidence interval and energy (OR: 1.21, 95% CI: 1.09-1.30) are positively associated with serum total BCAAs level, while FINS is negatively associated (OR: 0.20, 95% CI: 0.04-0.88). Simultaneously, the key enzymes of BCAAs decomposition, which promotes glycolysis by activating pyruvate dehydrogenase (PDH), are significantly increased.Conclusion
GBR improves the indicators of T2DM patients, and the underlying mechanisms include improving insulin resistance and accelerating catabolism of BCAAs.