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Can Rhodiola rosea supplementation mitigate digital eye strain? A triple-blinded placebo-controlled study.

  • 2025-08-27
  • Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) 45(7)
    • Paula M Lara
    • Jesús Vera
    • Daniel Marcos-Frutos
    • Carlos Alix-Fages
    • Pablo Jiménez-Martínez
    • Amador García-Ramos
    • Beatriz Redondo

Study Design

Type
Randomized Controlled Trial (RCT)
Population
Eighteen young adults (mean age ± SD: 24.6 ± 4.0 years)
Methods
Placebo-controlled, triple-blind, balanced crossover study; 1200 mg of RR or placebo per day for 4 days (two 300 mg capsules every 12 h); washout period of 3 days; four sessions separated by 1 week in a randomised order; sessions differed in supplement and cognitive demand of the visual task (Stroop test or control video); accommodative response measured at 500, 40 and 20 cm using open-field autorefractor; DES symptoms assessed via 10-item questionnaire
Blinding
Triple-blind
Duration
4 days
Funding
Unclear

Purpose

This study aimed to assess the impact of Rhodiola rosea (RR) supplementation on the dynamics of the accommodative response and digital eye strain (DES) symptoms following 30-min visual tasks with different levels of cognitive demand.

Methods

Eighteen young adults (mean age ± SD: 24.6 ± 4.0 years) participated in this placebo-controlled, triple-blind, balanced crossover study. Participants completed four sessions separated by 1 week in a randomised order. The sessions differed in the supplement (RR or placebo) and cognitive demand of the visual task (Stroop test or control video). The supplementation consisted of 1200 mg of RR or placebo per day for 4 days (two 300 mg capsules every 12 h) and a washout period of 3 days was allowed before the subsequent condition. The lag and variability of the accommodative response were measured at 500, 40 and 20 cm using an open-field autorefractor, and DES symptoms were assessed using a 10-item questionnaire.

Results

RR supplementation caused a reduction in the variability of accommodation (p = 0.007) and the perceived levels of 'Blurred vision when looking into the distance at the end of the near task' (p = 0.009). However, the lag of accommodation (p = 0.15) and the remainder of the DES symptoms were unaffected by the ingestion of RR (p > 0.05 in all cases). The reduction in the variability of accommodation after RR intake was observed at 40 and 20 cm (p-values <0.001 and 0.04, respectively), but not at far distance (500 cm, p = 0.40).

Conclusions

These findings show that RR supplementation (1200 mg/day for 4 days) produced a reduction in the variability of accommodation and one of the assessed DES symptoms, suggesting that it could be considered as a potential strategy to prevent or manage DES. However, further research is needed to determine its clinical relevance and optimise dosage and timing.

Research Insights

  • Rhodiola→Reduced Accommodation Variability

    RR supplementation caused a reduction in the variability of accommodation (p = 0.007)

    Effect
    Beneficial
    Effect size
    Small
    Dose
    1200 mg/day for 4 days
  • Rhodiola→Reduced Blurred Vision

    the perceived levels of 'Blurred vision when looking into the distance at the end of the near task' (p = 0.009)

    Effect
    Beneficial
    Effect size
    Small
    Dose
    1200 mg/day for 4 days
  • Rhodiola→Reduced Digital Eye Strain Symptoms

    the remainder of the DES symptoms were unaffected by the ingestion of RR (p > 0.05 in all cases)

    Effect
    Neutral
    Effect size
    Small
    Dose
    1200 mg/day for 4 days
  • Rhodiola→Reduced Lag of Accommodation

    the lag of accommodation (p = 0.15) ... were unaffected by the ingestion of RR

    Effect
    Neutral
    Effect size
    Small
    Dose
    1200 mg/day for 4 days
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