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Caries Inhibition by and Safety of Lactobacillus paracasei DSMZ16671

  • 2010-06-02
  • Journal of Dental Research 89(9)
    • J. Tanzer
    • A. Thompson
    • C. Lang
    • B. Cooper
    • L. Hareng
    • A. Gamer
    • A. Reindl
    • M. Pompejus

Abstract

Lactobacillus paracasei DSMZ16671, even if heat-killed, sensitively co-aggregates mutans streptococci specifically. Mutans streptococci are strongly implicated in caries induction in humans and rodents. We hypothesized: (1) that S. mutans recoveries from rats' teeth in vivo will decrease, with an associated decrease in caries, if these lactobacilli are fed to rats in an established caries model; and (2) that toxicological assays of these lactobacilli will show them to be benign. Four groups of specific-pathogen-free rats were formed: S. mutans 10449S-inoculated/16671-supplemented diet; un-inoculated/16671-supplemented diet; S. mutans 10449S-inoculated/placebo diet; and un-inoculated/placebo diet. Standard tests of toxicity and mutagenicity of heat-killed DSMZ16671 were performed. S. mutans recoveries were significantly reduced both in mid-experiment and at termination, as were caries lesion scores for the rats inoculated by S. mutans and fed the DSMZ16671 supplement, by comparison with controls. Neither toxicity nor mutagenicity of DSMZ16671 was detected. Use of heat-killed DSMZ16671 is efficacious in rats and appears safe.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus paracasei DSM 13434Absence of ToxicityNeutral
Large
Lactobacillus paracasei DSM 13434Reduced Caries RiskBeneficial
Large
Lactobacillus paracasei MCC1849No Mutagenicity, Teratogenicity, or GenotoxicityNeutral
Large
Lactobacillus paracasei MCC1849Reduced Caries LesionsBeneficial
Moderate
Lactobacillus paracasei MCC1849Reduced Streptococcus mutans RecoveriesBeneficial
Moderate

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