Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

Carnosine-enriched functional food enhances micro- and macrovascular endothelium-independent vasodilation in competitive athletes-a randomized study.

  • 2025-01-01
  • Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 50
    • Leon Perić
    • Ines Drenjančević
    • Ivana Jukić
    • Alina Boris
    • Petar Šušnjara
    • Nikolina Kolobarić
    • Zrinka Mihaljević
    • Zlata Kralik
    • Gordana Kralik
    • Manuela Košević
    • Olivera Galović
    • Ana Stupin

Study Design

Type
Randomized Controlled Trial (RCT)
Population
thirty-five healthy competitive male athletes
Methods
randomized interventional study, 3-week dietary protocol of carnosine-enriched chicken meat consumption
Duration
3-week dietary protocol
Funding
Unclear
This randomized interventional study aimed to investigate the effect of carnosine-enriched chicken meat consumption on systemic endothelium-dependent and -independent micro- and macrovascular reactivity in thirty-five healthy competitive male athletes. Both forearm skin micro- and macrovascular endothelium-independent vasodilation were increased, and diastolic and mean arterial blood pressure (BP) were decreased in Carnosine group (n = 19) following the 3-week dietary protocol. Microvascular endothelium-dependent response (post-occlusion reactive hyperemia) was increased in the Carnosine group and significantly associated with decreased mean arterial BP level. Following dietary protocol, Controls (n = 16) had substantially higher urate (but still normal) levels than the Carnosine group. Carnosine supplementation in the form of functional food enhances endothelium-dependent and vascular smooth muscle-dependent vasodilation in peripheral micro- and microcirculation. Carnosine's effect on vascular endothelium could be attributed to its BP-lowering effect. Results suggest that carnosine has the potential to resist hyperuricemia in healthy individuals. ClinicalTrials.gov (NCT05723939).

Research Insights

Back to top