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Cell-free whey from milk fermented with Bifidobacterium breve C50 used to modify the colonic microflora of healthy subjects.

  • 1998-05
  • Journal of Dairy Science 81(5)
    • M. Romond
    • Assia Ais
    • F. Guillemot
    • Rachid Bounouader
    • A. Cortot
    • C. Romond

Abstract

The ingestion of viable bacteria is thought to be required to modify intestinal microflora. In the present study, the effects on fecal flora of consumption of cell-free concentrated whey from milk that had been fermented with Bifidobacterium breve C50 was tested using 10 healthy human volunteers. Results were compared with effects of a commercial milk formula that had been fermented with Streptococcus thermophilus and B. breve C50 and given to 10 control subjects. Nitroreductase and beta-glucuronidase activities were assessed as risk indexes for colon carcinogenesis, and beta-galactosidase was measured as an indicator of the fermentation capacity of the colonic flora. Fecal excretion of Bacteroides fragilis, Clostridium perfringens, and clostridial spores decreased after 7 d of consumption of either preparation; however, counts of bifidobacteria only increased after intake of B. breve whey. Fecal pH was reduced from 7.1 +/- 0.2 to 6.6 +/- 0.3 after intake of whey that had been fermented with Bif. breve. Fecal nitroreductase and beta-glucuronidase significantly decreased, and beta-galactosidase activity increased, after consumption of either preparation. The results indicate that ingestion of viable bifidobacteria was not required to modify intestinal flora of humans. Repression of B. fragilis and clostridia seems to be independent of colonic bifidobacterial overgrowth in humans.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium breveIncreased Beta-Galactosidase ActivityBeneficial
Moderate
Bifidobacterium breveIncreased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium breveReduced Beta-Glucuronidase ActivityBeneficial
Moderate
Bifidobacterium breveReduced Faecal pHBeneficial
Small
Bifidobacterium breveReduced Fecal Excretion of Bacteroides FragilisBeneficial
Moderate
Bifidobacterium breveReduced Fecal Excretion of Clostridial SporesBeneficial
Moderate
Bifidobacterium breveReduced Fecal Excretion of Clostridium perfringensBeneficial
Moderate
Bifidobacterium breveReduced Fecal Nitroreductase ActivityBeneficial
Moderate
Bifidobacterium breve Bb-03Increased Beta-Galactosidase ActivityBeneficial
Moderate
Bifidobacterium breve Bb-03Increased Bifidobacterial CountsBeneficial
Moderate
Bifidobacterium breve Bb-03Reduced Faecal pHBeneficial
Small
Bifidobacterium breve Bb-03Reduced Harmful Bacteria Fecal ExcretionBeneficial
Moderate
Bifidobacterium breve BR03Increased Colonic Flora Fermentation CapacityBeneficial
Large
Bifidobacterium breve BR03Reduced Colon Cancer RiskBeneficial
Moderate
Bifidobacterium breve BR03Reduced Faecal pHBeneficial
Small
Bifidobacterium breve BR03Reduced Harmful BacteriaBeneficial
Moderate
Bifidobacterium breve BR-03Increased Beta-Galactosidase ActivityBeneficial
Moderate
Bifidobacterium breve BR-03Reduced Faecal pHBeneficial
Small
Bifidobacterium breve HA-129Increased Beta-Galactosidase ActivityBeneficial
Moderate
Bifidobacterium breve HA-129Reduced Faecal pHBeneficial
Small
Bifidobacterium breve MAK40B22BIncreased Beta-Galactosidase ActivityBeneficial
Moderate
Bifidobacterium breve MAK40B22BReduced Faecal pHBeneficial
Small
Bifidobacterium breve R0070Increased Beta-Galactosidase ActivityBeneficial
Moderate
Bifidobacterium breve R0070Reduced Beta-Glucuronidase ActivityBeneficial
Moderate
Bifidobacterium breve R0070Reduced Faecal pHBeneficial
Small
Bifidobacterium breve R0070Reduced Fecal Excretion of Bacteroides FragilisBeneficial
Moderate
Bifidobacterium breve R0070Reduced Fecal Excretion of Clostridial SporesBeneficial
Moderate
Bifidobacterium breve R0070Reduced Fecal Excretion of Clostridium perfringensBeneficial
Moderate
Bifidobacterium breve R0070Reduced Fecal Nitroreductase ActivityBeneficial
Moderate
Bifidobacterium breve Rosell-70Increased Beta-Galactosidase ActivityBeneficial
Moderate
Bifidobacterium breve Rosell-70Increased Bifidobacteria CountBeneficial
Moderate
Bifidobacterium breve Rosell-70Reduced Faecal pHBeneficial
Small
Bifidobacterium breve Rosell-70Reduced Fecal Excretion of Pathogenic BacteriaBeneficial
Moderate
Bifidobacterium breve SD5206Increased Beneficial BifidobacteriaBeneficial
Moderate
Bifidobacterium breve SD5206Increased Beta-Galactosidase ActivityBeneficial
Moderate
Bifidobacterium breve SD5206Reduced Faecal pHBeneficial
Small
Bifidobacterium breve UABbr-11Increased Bifidobacteria CountBeneficial
Moderate
Bifidobacterium breve UABbr-11Increased Colonic Flora Fermentation CapacityBeneficial
Large
Bifidobacterium breve UABbr-11Reduced Faecal pHBeneficial
Small
Bifidobacterium breve VPro 52Increased Beta-Galactosidase ActivityBeneficial
Moderate
Bifidobacterium breve VPro 52Increased Bifidobacteria CountBeneficial
Moderate
Bifidobacterium breve VPro 52Reduced Faecal pHBeneficial
Small
Bifidobacterium breve VPro 52Reduced Harmful BacteriaBeneficial
Moderate

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