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Streptococcus thermophilus, a food grade bacterium, is extensively used in the manufacture of fermented products such as yogurt and cheeses. It has been shown that S. thermophilus strains exhibited varying anti-inflammatory activities in vitro. Our previous study displayed that this activity could be partially due to peptide(s) generated by trypsin hydrolysis of the surface proteins of S. thermophilus LMD-9. Surface protease PrtS could be the source of these peptides during gastrointestinal digestion. Therefore, peptide hydrolysates were obtained by shaving two phenotypically distinct strains of S. thermophilus (LMD-9 PrtS+ and CNRZ-21N PrtS-) with pepsin, a gastric protease, followed or not by trypsinolysis. The peptide hydrolysates of both strains exhibited anti-inflammatory action through the modulation of pro-inflammatory mediators in LPS-stimulated THP-1 macrophages (COX-2, Pro-IL-1β, IL-1β, and IL-8) and LPS-stimulated HT-29 cells (IL-8). Therefore, peptides released from either PrtS+ or PrtS- strains in the gastrointestinal tract during digestion of a product containing this bacterium may display anti-inflammatory effects and reduce the risk of inflammation-related chronic diseases.

Keywords: Streptococcus thermophilus; inflammatory mediators; pepsin; surface proteins; trypsin.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Streptococcus thermophilus SL-21Reduced Proinflammatory MediatorsBeneficial
Streptococcus thermophilus ST-21Reduced Inflammation LevelsBeneficial
Streptococcus thermophilus UASt-09Reduced Inflammation LevelsBeneficial
Streptococcus thermophilus UASt-09Reduced Risk of Chronic Inflammatory DiseasesBeneficial

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