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Characterization of a Bacteriocin-Like Substance Produced by a Vaginal Lactobacillus salivariusStrain

  • 1999-12
  • Applied and Environmental Microbiology 65(12)
    • V. Ocaña
    • A. A. Pesce de Ruiz Holgado
    • M. Nader-Macías


A novel bacteriocin-like substance produced by vaginal Lactobacillus salivarius subsp. salivarius CRL 1328 with activity against Enterococcus faecalis, Enterococcus faecium, and Neisseria gonorrhoeae was characterized. The highest level of production of this heat-resistant peptide or protein occurred during the late exponential phase. Its mode of action was shown to be bactericidal. L. salivarius subsp. salivarius CRL 1328 could be used for the design of a probiotic to prevent urogenital infections.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus salivarius CRL 1328Reduced Urogenital InfectionsBeneficial

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