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Abstract

Lactobacillus plantarum Lp27 was isolated from Tibetan kefir grains. The Lp27 isolate survived a 3-h incubation at pH 2.0 and grew normally in 0.3% oxgall. In addition, the Lp27 isolate exhibited an adhesion ratio of 9.5 ± 2.5% with Caco-2 cells. Antibiotic susceptibility tests indicated that the Lp27 isolate was sensitive to gentamicin, tetracycline, erythromycin, and chloramphenicol, and was resistant to vancomycin with a minimum inhibitory value of 23µg/mL. The Lp27 isolate inhibited cholesterol absorption through downregulation of Niemann-Pick C1-like 1 (NPC1L1) expression in Caco-2 cells. The Lp27 isolate was fed to hypercholesterolemic rats at a dose of 10(9) cfu/d for 4wk. The Lp27 feeding significantly lowered serum total cholesterol, low-density lipoprotein cholesterol, and triglycerides concentrations, but no change was observed in the serum high-density lipoprotein cholesterol concentrations. In addition, liver total cholesterol and triglycerides were decreased in the Lp27-fed group. The expression of NPC1L1 in the duodenum and jejunum was significantly decreased following Lp27 feeding. These results indicate that Lp27 might be an effective cholesterol-lowering probiotic and a possible mechanism for the cholesterol-reducing effects of probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactiplantibacillus plantarum LP-01No Change in High Density LipoproteinsNeutral
Small
Lactiplantibacillus plantarum LP-01Reduced Liver Cholesterol LevelsBeneficial
Large
Lactiplantibacillus plantarum LP-01Reduced Liver Triglyceride ContentBeneficial
Moderate
Lactiplantibacillus plantarum LP-01Reduced Low-Density Lipoprotein CholesterolBeneficial
Large
Lactiplantibacillus plantarum LP-01Reduced Serum Total CholesterolBeneficial
Moderate
Lactiplantibacillus plantarum LP-01Reduced TriglyceridesBeneficial
Large
Lactiplantibacillus plantarum LP-1Reduced LDL CholesterolBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Liver Total CholesterolBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Liver TriglyceridesBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced NPC1L1 ExpressionBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Total Cholesterol LevelsBeneficial
Large
Lactiplantibacillus plantarum LP-1Reduced TriglyceridesBeneficial
Large
Lactiplantibacillus plantarum Lp-115Reduced Liver Cholesterol LevelsBeneficial
Large
Lactiplantibacillus plantarum Lp-115Reduced Liver Triglyceride ContentBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Reduced Low-Density Lipoprotein CholesterolBeneficial
Large
Lactiplantibacillus plantarum Lp-115Reduced Serum Total CholesterolBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Reduced TriglyceridesBeneficial
Large
Lactiplantibacillus plantarum Lp-115Stable High-Density Lipoprotein Cholesterol LevelNeutral
Small
Lactobacillus kefirReduced LDL CholesterolBeneficial
Moderate
Lactobacillus kefirReduced Liver Total CholesterolBeneficial
Moderate
Lactobacillus kefirReduced Liver TriglyceridesBeneficial
Moderate
Lactobacillus kefirReduced Serum Total CholesterolBeneficial
Moderate
Lactobacillus kefirReduced TriglyceridesBeneficial
Large
Lactobacillus kefiriReduced LDL CholesterolBeneficial
Moderate
Lactobacillus kefiriReduced Liver Total CholesterolBeneficial
Moderate
Lactobacillus kefiriReduced Liver TriglyceridesBeneficial
Moderate
Lactobacillus kefiriReduced Serum Total CholesterolBeneficial
Moderate
Lactobacillus kefiriReduced Serum TriglyceridesBeneficial
Moderate
Lactobacillus plantarum LP-01Reduced LDL CholesterolBeneficial
Moderate
Lactobacillus plantarum LP-01Reduced Liver Total CholesterolBeneficial
Moderate
Lactobacillus plantarum LP-01Reduced Liver TriglyceridesBeneficial
Moderate
Lactobacillus plantarum LP-01Reduced Serum Total CholesterolBeneficial
Moderate
Lactobacillus plantarum LP-01Reduced Serum TriglyceridesBeneficial
Moderate
Lactobacillus plantarum LP09Reduced Intestinal Cholesterol AbsorptionBeneficial
Large
Lactobacillus plantarum LP09Reduced LDL CholesterolBeneficial
Moderate
Lactobacillus plantarum LP09Reduced Liver Total CholesterolBeneficial
Moderate
Lactobacillus plantarum LP09Reduced Liver TriglyceridesBeneficial
Moderate
Lactobacillus plantarum LP09Reduced Serum Total CholesterolBeneficial
Moderate
Lactobacillus plantarum LP09Reduced TriglyceridesBeneficial
Large
Lactobacillus plantarum Lp-115Reduced LDL CholesterolBeneficial
Moderate
Lactobacillus plantarum Lp-115Reduced Liver Total CholesterolBeneficial
Moderate
Lactobacillus plantarum Lp-115Reduced Liver TriglyceridesBeneficial
Moderate
Lactobacillus plantarum Lp-115Reduced Serum Total CholesterolBeneficial
Moderate
Lactobacillus plantarum Lp-115Reduced Triglyceride LevelsBeneficial
Large

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