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Abstract

The bacterium Lactobacillus plantarum PH04 was isolated from infant feces and tested positive for bile/acid tolerance and bile salt hydrolase activity. It was evaluated as a potential probiotic with cholesterol-lowering effect. Bile salt hydrolase activity was nine times greater in stationary phase than in exponential phase cells and increased when the cells were exposed to conjugated bile salts. L. plantarum PH04 was resistant to seven of nine antibiotics tested and did not produce beta-glucuronidase. L. plantarum PH04 was fed to hypercholesterolemic mice at numbers of 10(7) CFU per mouse per day for 14 days. Compared with a control group, the serum cholesterol and triglycerides were respectively 7 and 10% lower in the group fed L. plantarum PH04, and fecal lactic acid bacteria increased while no any significant differences (P<0.05) in body weight, visceral weigh index or bacteria translocation between two groups were observed. The results indicated that L. plantarum PH04 might be effective as a probiotic with cholesterol-lowering activities.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarum DSM 6595Increased Fecal Lactic Acid Bacteria CountsBeneficial
Moderate
Lactobacillus plantarum DSM 6595Reduced Serum CholesterolBeneficial
Small
Lactobacillus plantarum DSM 6595Reduced TriglyceridesBeneficial
Small
Lactobacillus plantarum HA-119Increased Lactic Acid Bacteria LevelsBeneficial
Small
Lactobacillus plantarum HA-119Reduced Serum TriglyceridesBeneficial
Small
Lactobacillus plantarum HA-119Reduced Total Cholesterol LevelsBeneficial
Small
Lactobacillus plantarum Rosell-1012Increased Lactic Acid Bacteria LevelsBeneficial
Small
Lactobacillus plantarum Rosell-1012Reduced Serum Cholesterol LevelsBeneficial
Small
Lactobacillus plantarum Rosell-1012Reduced Serum Triglyceride LevelsBeneficial
Small
Lactobacillus plantarum SD5209Change in Body WeightNeutral
Small
Lactobacillus plantarum SD5209Increased Lactic Acid Bacteria LevelsBeneficial
Small
Lactobacillus plantarum SD5209Reduced Serum Cholesterol LevelsBeneficial
Small
Lactobacillus plantarum SD-5209Increased Lactic Acid Bacteria LevelsBeneficial
Small
Lactobacillus plantarum SD-5209Reduced Cholesterol LevelsBeneficial
Small
Lactobacillus plantarum SD-5209Reduced Serum Triglyceride LevelsBeneficial
Small
Lactobacillus plantarum VPro 10Increased Lactic Acid Bacteria LevelsBeneficial
Small
Lactobacillus plantarum VPro 10Reduced Serum TriglyceridesBeneficial
Small
Lactobacillus plantarum VPro 10Reduced Total Cholesterol LevelsBeneficial
Small

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