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Clinical Effects of Lactobacillus rhamnosus in Non-Surgical Treatment of Chronic Periodontitis: A Randomized Placebo-Controlled Trial With 1-Year Follow-Up.

  • 2016-08
  • Journal of Periodontology 87(8)
    • Alicia Morales
    • P. Carvajal
    • Nora Silva
    • Marcela Hernández
    • C. Godoy
    • G. Rodríguez
    • R. Cabello
    • Jocelyn García-Sesnich
    • A. Hoare
    • P. Diaz
    • J. Gamonal


Background: Probiotics are living microorganisms that provide beneficial effects for the host when administered in proper quantities. The aim of this double-masked placebo-controlled parallel-arm randomized clinical trial is to evaluate the clinical effects of a Lactobacillus rhamnosus SP1-containing probiotic sachet as an adjunct to non-surgical therapy.

Methods: Twenty-eight systemically healthy volunteers with chronic periodontitis were recruited and monitored clinically at baseline and 3, 6, 9, and 12 months after therapy. Clinical parameters measured included plaque accumulation, bleeding on probing, probing depths (PDs), and clinical attachment loss. Patients received non-surgical therapy, including scaling and root planing (SRP), and were assigned randomly to a test (SRP + probiotic, n = 14) or control (SRP + placebo, n = 14) group. The intake, once a day for 3 months, of an L. rhamnosus SP1 probiotic sachet commenced after the last session of SRP.

Results: Both test and control groups showed improvements in clinical parameters at all time points evaluated. However, the test group showed greater reductions in PD than the control. Also, at initial visits and after 1-year follow-up, the test group showed a statistically significant reduction in the number of participants with PD ≥6 mm, indicating a reduced need for surgery, in contrast to the placebo group.

Conclusion: The results of this trial indicate that oral administration of L. rhamnosus SP1 resulted in similar clinical improvements compared with SRP alone.

Keywords: Chronic periodontitis; Lactobacillus rhamnosus; probiotics; root planing.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus rhamnosusImproved Probing DepthBeneficial
Lactobacillus rhamnosusReduced Surgical InterventionBeneficial
Lactobacillus rhamnosus DSM33560Reduced Periodontal Pocket Depth ≥6 mmBeneficial
Lactobacillus rhamnosus DSM33560Reduced Probing DepthsBeneficial
Lactobacillus rhamnosus Lr-32Reduced Need for Periodontitis SurgeryBeneficial
Lactobacillus rhamnosus Lr-32Reduced Probing Depths in Chronic PeriodontitisBeneficial
Lactobacillus rhamnosus lysate powderImproved Periodontitis SymptomsBeneficial
Lactobacillus rhamnosus lysate powderReduced Need for Periodontitis SurgeryBeneficial
Lactobacillus rhamnosus lysate powderReduced Probing DepthsBeneficial
Lactobacillus rhamnosus NH001Reduced Probing Depths in Chronic PeriodontitisBeneficial
Lactobacillus rhamnosus R0343NDReduced Probing DepthsBeneficial

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