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Abstract

Background: Streptococcus salivarius K12 has been shown to inhibit the growth of Streptococcus pyogenes due to bacteriocins release. Because of its ability to colonize the oral cavity, we have tested the strain K12 for its efficacy in preventing streptococcal pharyngitis and/or tonsillitis in adults.

Methods: Forty adults with a diagnosis of recurrent oral streptococcal pharyngitis were enrolled in the study. Twenty of these subjects took for 90 days a tablet containing Streptococcus salivarius K12 (Bactoblis®). The other 20 subjects served as untreated controls. A 6-month follow-up was included to evaluate any persistent protective role.

Results: The 20 adults who completed the 90-day course of Bactoblis® showed a reduction in their episodes of streptococcal pharyngeal infection (about 80%). The 90 days treatment was also associated with an approximately 60% reduction in the incidence of reported pharyngitis in the 6-month period following use of the product. The product was well tolerated by the subjects with no treatment-related side effects or drop-outs reported.

Conclusion: Prophylactic administration of Streptococcus salivarius K12 to adults having a history of recurrent oral streptococcal pathology reduced the number of episodes of streptococcal pharyngeal infections and/or tonsillitis.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Streptococcus salivariusAbsence of Treatment-Related Side EffectsBeneficial
Moderate
Streptococcus salivariusReduced Frequency of PharyngitisBeneficial
Large
Streptococcus salivariusReduced Frequency of Streptococcal Pharyngeal InfectionsBeneficial
Large
Streptococcus salivarius BLIS K12Absence of Treatment-Related Side EffectsBeneficial
Moderate
Streptococcus salivarius BLIS K12Reduced Frequency of Streptococcal Pharyngeal InfectionsBeneficial
Large
Streptococcus salivarius BLIS K12Reduced Incidence of PharyngitisBeneficial
Moderate
Streptococcus salivarius K12Absence of Treatment-Related Side EffectsBeneficial
Moderate
Streptococcus salivarius K12Reduced Frequency of Streptococcal Pharyngeal InfectionsBeneficial
Large
Streptococcus salivarius K12Reduced Incidence of PharyngitisBeneficial
Moderate

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