Clinical Implications of COVID-19-Related Endothelial Dysfunction.
- 2024-08
- JACC. Advances 3(8)
- Michael Aljadah
- Nabeel Khan
- Andreas M Beyer
- Yiliang Chen
- Andrew Blanker
- Michael E Widlansky
- PubMed: 39055276
- DOI: 10.1016/j.jacadv.2024.101070
Study Design
- Type
- Review
Endothelial dysfunction represents a measurable and early manifestation of vascular disease. Emerging evidence suggests cardiovascular risk remains elevated after COVID-19 infection for at least 12 months, regardless of cardiovascular disease status prior to infection. We review the relationship between the severity of endothelial dysfunction and the severity of acute COVID-19 illness, the degree of impairment following recovery in both those with and without postacute sequalae SARS-CoV-2 infection, and current therapeutic efforts targeting endothelial function in patients following COVID-19 infection. We identify gaps in the literature to highlight specific areas where clinical research efforts hold promise for progress in understanding the connections between endothelial function, COVID-19, and clinical outcomes that will lead to beneficial therapeutics.