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Comparison of the effectiveness of Morus alba and chlorhexidine gels as an adjunct to scaling and root planing on stage II periodontitis - A randomized controlled clinical trial.

  • 2024-01-15
  • International journal of dental hygiene 22(3)
    • Shilpa Gunjal
    • Vinuta Hampiholi
    • Anil V Ankola
    • Deepak Gowda Sadashivappa Pateel

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 180
Population
180 patients with stage II periodontitis
Methods
single-blind, randomized controlled trial; full-mouth SRP; randomly assigned to chlorhexidine digluconate gel, Morus alba gel, or placebo gel at baseline, 15 days and 30 days
Blinding
Single-blind
Duration
45 days
  • Large Human Trial

Objectives

The present study aimed to assess and compare the effect of Morus alba and chlorhexidine gel as an adjunct to scaling and root planing (SRP) in treating stage II periodontitis.

Methods

A single-blind, randomized controlled trial was conducted on 180 patients with stage II periodontitis who received full-mouth SRP. They were randomly assigned to receive chlorhexidine digluconate (CHX) gel, Morus alba (MA) and placebo gel for Groups A, B and C, respectively, at the baseline, 15 days and 30 days. Plaque index (PI), Gingival index (GI), periodontal pocket depth (PPD) and quantitative analysis (culture) of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythia were assessed at baseline and 45 days. Analysis of variance was used to compare the significant difference in PI, GI, PPD and microbiological parameters between the three groups after the intervention, followed by post hoc Mann-Whitney U and Tukey's HSD test for clinical and microbiological parameters, respectively.

Results

Intergroup comparison of the PI, GI and microbiological parameters between the MA and CHX groups at the end of 45 days did not show a statistically significant difference (p > 0.05), whereas a statistically significant difference was observed for PPD between MA and CHX groups with the mean difference of 0.18 mm (p = 0.002).

Conclusion

Morus alba gel was found to be effective in decreasing PPD. However, there was no difference between Morus alba and chlorhexidine gel as an adjunct to SRP in treating stage II periodontitis.

Research Insights

  • White Mulberry→Reduced Gingival Index

    Intergroup comparison of the PI, GI and microbiological parameters between the MA and CHX groups at the end of 45 days did not show a statistically significant difference (p>0.05)

    Effect
    Neutral
    Effect size
    Small
  • White Mulberry→Reduced Plaque Index

    Intergroup comparison of the PI, GI and microbiological parameters between the MA and CHX groups at the end of 45 days did not show a statistically significant difference (p>0.05)

    Effect
    Neutral
    Effect size
    Small
  • White Mulberry→Reduced Probing Pocket Depth

    whereas a statistically significant difference was observed for PPD between MA and CHX groups with the mean difference of 0.18mm (p=0.002)

    Effect
    Beneficial
    Effect size
    Small
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