Complete genome sequence of the Bifidobacterium animalis subspecies lactis BL3, preventive probiotics for acute colitis and colon cancer
- 2017-09
- New Microbes and New Infections 19
- Jisu Kang
- Won-Hyong Chung
- Tae-Joong Lim
- S. Lim
- Y. Nam
- PubMed: 28702200
- DOI: 10.1016/j.nmni.2017.05.012
Abstract
We report the genome sequence of Bifidobacterium animalis subspecies lactis BL3, which has preventive properties on acute colitis and colon cancer. The genome of BL3, which was isolated from Korean faeces, consisted of a 1 944 323 bp size single chromosome, and its G+C content was 60.5%. Genome comparison against the closest Bifidobacterium animalis strain revealed that BL3 had particularly different regions of four areas encoding flavin-nucleotide-binding protein, transposase, multidrug ABC transporter and ATP binding protein.
Keywords: Bifidobacterium; IBD; PacBio; genome sequence; probiotics.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bifidobacterium animalis subsp. lactis BLC1 | Reduced Incidence of Acute Colitis | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BLC1 | Reduced Incidence of Colon Cancer | Beneficial | Moderate |
| Bifidobacterium lactis BL818 | Reduced Colon Cancer Risk | Beneficial | Large |
| Bifidobacterium lactis BL818 | Reduced Severity of Acute Colitis | Beneficial | Large |
| Bifidobacterium lactis BLC-1 | Reduced Incidence of Acute Colitis | Beneficial | Moderate |
| Bifidobacterium lactis BLC-1 | Reduced Incidence of Colon Cancer | Beneficial | Moderate |