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Consumption effect of a synbiotic beverage made from soy and yacon extracts containing Bifidobacterium animalis ssp. lactis BB-12 on the intestinal polyamine concentrations in elderly individuals.

  • 2017-09
  • Food Research International 99
    • M. Manzoni
    • E. Rossi
    • N. D. Pauly-Silveira
    • R. A. Pinto
    • M. N. Roselino
    • I. Carlos
    • M. B. Quilles
    • Maria Beatriz de Abreu Glória
    • D. Cavallini

Abstract

This study aimed to investigate the effect of a synbiotic beverage made from soy and yacon (Smallanthus sonchifolius) extracts containing Bifidobacterium animalis ssp. lactis BB-12 on healthy elderly individuals' intestinal polyamine concentrations. A randomized, double-blinded, placebo-controlled trial has been conducted with twenty-nine volunteers (over 65years of age) who either had a daily intake of 150mL of synbiotic (synbiotic group - S) or placebo (placebo group - P) beverages. Both had the same nutrient composition, except that a probiotic culture was added to the synbiotic beverage. Total experiment time was 8weeks, which was divided into 3 consecutive phases: a prefeeding period (2weeks), followed by a feeding period (4weeks) and a postfeeding period (2weeks). Stool samples were collected at 3 time periods. Fecal concentrations of polyamines, putrescine (PUT), cadaverine (CAD) and spermidine (SPD) that were obtained during the synbiotic and placebo consumption period were significantly higher (p<0.05) than those found during the pre-consumption baseline level period. No significant differences in the number of bifidobacteria, clostridia, or enterobacteria were observed in any of the two groups at the three time periods. Similarly, no significant effect on the production of proinflammatory cytokines tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and anti-inflammatory interleukin-10 (IL-10) was induced by the synbiotic or placebo beverages consumption. The results herein indicate that both the synbiotic and the placebo beverage consumption have increased polyamines levels, which are often reduced in elderly individuals, without influencing inflammatory responses. In addition, both placebo and synbiotic beverages seems to contribute by maintaining increased polyamines levels.

Keywords: Bifidobacterium; Elderly; Gut environment; Polyamine; Soy; Yacon.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
BifidobacteriumIncreased Intestinal Polyamine LevelsBeneficial
Moderate
BifidobacteriumStable Inflammatory ResponsesNeutral
Small
Bifidobacterium animalisIncreased Intestinal Polyamine LevelsBeneficial
Moderate
Bifidobacterium animalisUnchanged Inflammatory ResponseNeutral
Small
Bifidobacterium animalis subsp. lactisIncreased Polyamine LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BB-12Increased Intestinal Polyamine LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BB-12Maintained Gut Microbiota CompositionNeutral
Small
Bifidobacterium animalis subsp. lactis BB-12Unchanged Inflammatory ResponseNeutral
Small
Bifidobacterium animalis subsp. lactis BS-01Enhanced Inflammatory ResponseNeutral
Small
Bifidobacterium animalis subsp. lactis BS-01Increased Polyamine LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Increased Polyamine LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Stable Inflammatory ResponsesNeutral
Small
Bifidobacterium bifidum BB01Increased Intestinal Polyamine LevelsBeneficial
Moderate
Bifidobacterium bifidum BB01Unchanged Inflammatory Marker ProductionNeutral
Small
Bifidobacterium bifidum/lactis Bb-02Increased Polyamine LevelsBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Unchanged Inflammatory ResponseNeutral
Small
Bifidobacterium lactisIncreased Intestinal Polyamine LevelsBeneficial
Moderate
Bifidobacterium lactisUnchanged Inflammatory ResponseNeutral
Small
Bifidobacterium lactis Bb-02Increased Polyamine LevelsBeneficial
Moderate
Bifidobacterium lactis Bb-02Unchanged Inflammatory ResponseNeutral
Small
Bifidobacterium lactis BB-12Increased Intestinal Polyamine LevelsBeneficial
Moderate
Bifidobacterium lactis Bi-07Increased Polyamine LevelsBeneficial
Moderate
Bifidobacterium lactis Bi-07Unchanged Inflammatory ResponseNeutral
Small
Bifidobacterium lactis Bl-04Increased Polyamine LevelsBeneficial
Moderate
Bifidobacterium lactis Bl-04No Change in Inflammatory or Anti-inflammatory Cytokine LevelsNeutral
Small
Bifidobacterium lactis Bl-04Stable Bacterial PopulationsNeutral
Small
Bifidobacterium lactis BLA80Increased Polyamine LevelsBeneficial
Moderate
Bifidobacterium lactis BLA80Unchanged Inflammatory ResponseNeutral
Small
Bifidobacterium lactis DSM 15954Increased Polyamine LevelsBeneficial
Moderate
Bifidobacterium lactis DSM 15954Stable Bacterial PopulationsNeutral
Small
Bifidobacterium lactis DSM 15954Unchanged Inflammatory ResponseNeutral
Small
Bifidobacterium lactis ISS BifIncreased Polyamine LevelsBeneficial
Moderate
Bifidobacterium lactis ISS BifNo Significant Change in Inflammatory ResponsesNeutral
Small
Bifidobacterium lactis MAK16B42LIncreased Intestinal Polyamine LevelsBeneficial
Moderate
Bifidobacterium lactis MAK16B42LMaintained Polyamine LevelsBeneficial
Small
Bifidobacterium lactis MAK16B42LUnchanged Gut Microbiota CompositionNeutral
Small
Bifidobacterium lactis MAK16B42LUnchanged Inflammatory Marker LevelsNeutral
Small
Bifidobacterium lactis R101-8Increased Polyamine LevelsBeneficial
Moderate
Bifidobacterium lactis R101-8Stable Inflammatory ResponsesNeutral
Small
Bifidobacterium lactis UABla-12Increased Intestinal Polyamine LevelsBeneficial
Moderate
Bifidobacterium lactis UABla-12Unchanged Inflammatory ResponseNeutral
Small

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