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Abstract

Background. Minor digestive symptoms are common and dietary approaches such as probiotic administration or fibre and fermentable carbohydrate intake adjustments are often recommended. A Fermented Milk Product (FMP) containing Bifidobacterium animalis subsp. lactis CNCM I-2494 and lactic acid bacteria has been shown to improve digestive symptoms after 4 weeks of consumption, but the speed of onset of this effect and its dependence on fibre intake or physical activity is unknown. To answer these questions, data from two previously published trials on FMP for minor digestive symptoms were combined. Methods. In total, 538 participants provided weekly assessments of bloating, abdominal pain/discomfort, flatulence, borborygmi/rumbling stomach from which a composite score was calculated. At baseline in one study (n = 336), dietary fibre consumption was recorded and physical activity classified as high, moderate or low. The speed of the FMP's effect was assessed by a repeated measure analysis of variance measuring the change from baseline for the composite score of digestive symptoms. Results. FMP consumption resulted in a significant decrease in the composite score of symptoms after only 2 weeks in both studies and the pooled data at week 1 (-0.35 [-0.69, 0.00]; p = 0.05), week 2 (-0.66 [-1.04, -0.27]; p < 0.001), week 3 (-0.49 [-0.89, -0.10]; p = 0.01) and week 4 (-0.46 [-0.88, -0.04]; p = 0.03). The interactions fibre intake-by-product group, physical activity-by-product group and time-by-product group were not statistically significant. Conclusion. FMP consumption leads to a rapid improvement in symptoms which is likely to encourage adherence to this dietary intervention. This effect is independent of dietary fibre and physical activity.

Keywords: Bifidobacterium lactis CNCM I-2494; diet; digestive symptoms; gastrointestinal discomfort; physical activity; probiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium lactisImproved Digestive SymptomsBeneficial
Moderate
Bifidobacterium lactis B420Reduced Minor Digestive SymptomsBeneficial
Moderate
Bifidobacterium lactis BI-04Improved Digestive SymptomsBeneficial
Moderate
Bifidobacterium lactis Bi-07Improved Digestive SymptomsBeneficial
Moderate
Bifidobacterium lactis Bl-04Reduced Digestive SymptomsBeneficial
Moderate
Bifidobacterium lactis BL818Improved Digestive SymptomsBeneficial
Moderate
Bifidobacterium lactis BLA80Improved Digestive SymptomsBeneficial
Moderate
Bifidobacterium lactis HA-194Improved Digestive SymptomsBeneficial
Moderate
Bifidobacterium lactis ISS BifImproved Digestive SymptomsBeneficial
Moderate
Bifidobacterium lactis MAK16B42LReduced Digestive SymptomsBeneficial
Moderate
Bifidobacterium lactis SD-5219Reduced Digestive SymptomsBeneficial
Moderate
Bifidobacterium lactis VK2Improved Digestive SymptomsBeneficial
Moderate

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