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Current Progress and Future Perspectives on the Use of Bacillus clausii

  • 2022-06-17
  • Microorganisms 10(6)
    • E. Ghelardi
    • A. T. Abreu y Abreu
    • Christian Boggio Marzet
    • G. Álvarez Calatayud
    • M. I. Perez
    • Ana Paula Moschione Castro


Bacillus clausii is a probiotic that benefits human health. Its key characteristics include the ability to form spores; the resulting tolerance to heat, acid, and salt ensures safe passage through the human gastrointestinal tract with no loss of cells. Although B. clausii has been widely used for many decades, the beneficial properties of other probiotics, such as Lactobacillus spp. and Bifidobacterium spp., are better disseminated in the literature. In this review, we summarize the physiological, antimicrobial, and immunomodulatory properties of probiotic B. clausii strains. We also describe findings from studies that have investigated B. clausii probiotics from the perspective of quality and safety. We highlight innovative properties based on biochemical investigations of non-probiotic strains of B. clausii, revealing that B. clausii may have further health benefits in other therapeutic areas.

Keywords: Alkalihalobacillus clausii; Bacillus clausii; Bacillus spores; Bacillus subtilis; dysbiosis; gut barrier; gut microbiota; immunomodulation; probiotics; spore probiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bacillus clausiiAdditional Therapeutic BenefitsBeneficial
Bacillus clausiiEnhanced Antimicrobial ActivityBeneficial
Bacillus clausiiEnhanced Immunomodulatory FunctionBeneficial
Bacillus clausiiImproved Gastrointestinal ToleranceBeneficial
Bacillus clausiiImproved Physiological ParametersBeneficial

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