Skip to main content

Abstract

Purpose: The effects of heat-killed Lactobacillus plantarum L-137 (HK L-137) on inflammation and lipid metabolism were investigated in overweight volunteers.

Methods: One hundred healthy subjects with a body mass index from 23.0 to 29.9 (51 men and 49 women; mean age: 41.4 years) were enrolled in this randomized, double-blind, placebo-controlled, parallel group study. Subjects were randomly assigned to daily administration of a tablet containing HK L-137 (10 mg) or a placebo tablet for 12 weeks. Blood samples were collected every 4 weeks to measure biomarkers of lipid metabolism and inflammatory mediators.

Results: The percent change of concanavalin A-induced proliferation of peripheral blood mononuclear cells was significantly larger in the HK L-137 group than in the control group, similar to previous studies. The decreases of aspartate aminotransferase and alanine aminotransferase over time were significantly larger in the HK L-137 group than in the control group, as were the decreases of total cholesterol, low-density lipoprotein cholesterol, and the leukocyte count at one time point. These effects of HK L-137 were stronger in the subjects with higher C-reactive protein levels.

Conclusions: These findings suggest that daily intake of HK L-137 can improve inflammation and lipid metabolism in subjects at risk of inflammation.

Keywords: Heat-killed bacteria; Inflammation; Lactobacillus plantarum; Lipid metabolism; Overweight subjects.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarumImproved Inflammation LevelsBeneficial
Moderate
Lactobacillus plantarumImproved Lipid MetabolismBeneficial
Moderate
Lactobacillus plantarumReduced Elevated Liver EnzymesBeneficial
Moderate
Lactobacillus plantarumReduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum HA-119Improved Lipid ProfileBeneficial
Moderate
Lactobacillus plantarum HA-119Increased C-Reactive Protein LevelsBeneficial
Moderate
Lactobacillus plantarum HA-119Reduced InflammationBeneficial
Moderate
Lactobacillus plantarum HA-119Reduced Liver Enzyme LevelsBeneficial
Moderate
Lactobacillus plantarum L-137Improved Lipid MetabolismBeneficial
Moderate
Lactobacillus plantarum L-137Reduced Inflammation LevelsBeneficial
Moderate
Lactobacillus plantarum N13Improved Inflammatory ResponseBeneficial
Moderate
Lactobacillus plantarum Rosell-AImproved Immune ResponseBeneficial
Moderate
Lactobacillus plantarum Rosell-AImproved Lipid ProfileBeneficial
Moderate
Lactobacillus plantarum Rosell-AReduced Inflammation LevelsBeneficial
Moderate
⬆ Back to top
Pillser
Supplement Research and Comparison Website: evidence-based information about supplements, their benefits, potential risks, and their efficacy.
Receive updates about our products, services, sales, and special offers. Unsubscribe anytime. See our Privacy Policy for details on how we handle your information.

Join Our Community

Use support@pillser.com to get in touch.