Detection of pathogens and vaccine design strategies for Streptococcus pneumoniae.
- 2025-10
- Microbial pathogenesis 207
- Jinlong Zhang
- Huiling Ma
- Fuyong Liu
- Zhilong Zhao
- Xiaohui Zhao
- Yongsheng Xie
- Bao Wang
- Xiaomeng Li
- Rui Li
- Jinwen Sima
- Bing Zhang
- Xuejiao Li
- PubMed: 40669214
- DOI: 10.1016/j.micpath.2025.107896
Study Design
- Type
- Review
Streptococcus pneumoniae, often referred to as S. pneumoniae, plays a critical role in numerous infectious conditions, notably targeting the respiratory system with diseases such as lobar pneumonia, bronchitis, and pleurisy. This bacterium is the predominant cause of bacterial pneumonia in children and a major agent of bacterial meningitis in those over three months of age. Moreover, S. pneumoniae accounts for significant childhood mortality, with approximately one million deaths each year among children younger than five globally, as reported by the World Health Organization. These infections pose a severe threat to public health and are becoming a paramount concern worldwide. Despite extensive utilization of pneumococcal vaccines, such as polysaccharide and conjugate forms, the limited spectrum of these vaccines and the rise of non-vaccine serotypes necessitate the development of novel preventive strategies. The escalation of drug-resistant S. pneumoniae strains further complicates this issue, diminishing the effectiveness of traditional antibiotics and amplifying the need for vigilant monitoring and the creation of superior vaccines. This article meticulously reviews progress in the surveillance and vaccine development for S. pneumoniae. It provides a detailed comparative assessment of existing pathogen detection methods and vaccine development techniques, examining their advantages and shortcomings. Additionally, the study delves into the evolving challenges and future directions in pneumococcal vaccine research, offering essential references that enhance understanding of both pathogen surveillance and vaccine innovation.