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Developing oral probiotics from Streptococcus salivarius.

  • 2012-12
  • Future Microbiology 7(12)
    • P. Wescombe
    • J. Hale
    • N. Heng
    • J. Tagg

Abstract

Considerable human illness can be linked to the development of oral microbiota disequilibria. The predominant oral cavity commensal, Streptococcus salivarius has emerged as an important source of safe and efficacious probiotics, capable of fostering more balanced, health-associated oral microbiota. Strain K12, the prototype S. salivarius probiotic, originally introduced to counter Streptococcus pyogenes infections, now has an expanded repertoire of health-promoting applications. K12 and several more recently proposed S. salivarius probiotics are now being applied to control diverse bacterial consortia infections including otitis media, halitosis and dental caries. Other potential applications include upregulation of immunological defenses against respiratory viral infections and treatment of oral candidosis. An overview of the key steps required for probiotic development is also presented.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Streptococcus salivarius BLIS K12Enhanced Immune ResponseBeneficial
Large
Streptococcus salivarius BLIS K12Improved Control of Otitis MediaBeneficial
Moderate
Streptococcus salivarius BLIS K12Reduced Caries RiskBeneficial
Moderate
Streptococcus salivarius BLIS K12Reduced HalitosisBeneficial
Moderate
Streptococcus salivarius BLIS K12Reduced Risk of S. pyogenes InfectionBeneficial
Moderate
Streptococcus salivarius BLIS K12Treated Oral CandidosisBeneficial
Moderate
Streptococcus salivarius K12Enhanced Immunological Defense Against Respiratory Viral InfectionsBeneficial
Small
Streptococcus salivarius K12Reduced Acute Otitis MediaBeneficial
Moderate
Streptococcus salivarius K12Reduced Caries RiskBeneficial
Moderate
Streptococcus salivarius K12Reduced HalitosisBeneficial
Moderate
Streptococcus salivarius K12Reduced Risk of S. pyogenes InfectionBeneficial
Moderate
Streptococcus salivarius K12Treated Oral CandidosisBeneficial
Moderate
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