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Dietary Heat-Killed Lactobacillus brevis SBC8803 Attenuates Chronic Sleep Disorders Induced by Psychophysiological Stress in Mice.

  • 2019-04-30
  • Journal of Nutritional Science and Vitaminology 65(2)
    • Sayaka Higo-Yamamoto
    • Saori Yamamoto
    • K. Miyazaki
    • Y. Nakakita
    • H. Kaneda
    • Y. Takata
    • Takeshi Nakamura
    • K. Oishi

Abstract

We previously reported that dietary heat-killed Lactobacillus brevis SBC8803 affects sleep in mice and humans. The present study examined whether SBC8803 improves psychophysiological stress-induced chronic sleep disorders (CSD) using a mouse model characterized by disrupted circadian rhythms of wheel-running activity and sleep-wake cycles. Mice were fed with a diet supplemented with 0.5% heat-killed SBC8803 for 6 wk and imposed stress-induced CSD for last 2 wk. Dietary SBC8803 suppressed the reduction in wheel-running activity induced by CSD. Electroencephalography (EEG) revealed that SBC8803 significantly restored wakefulness and increased non-rapid eye movement (NREM) sleep during the second half of the active phase during CSD. The CSD-induced reduction in EEG slow wave activity, a marker of NREM sleep intensity, during the beginning of the inactive phase was significantly improved by SBC8803 supplementation. These findings suggest that dietary heat-killed SBC8803 confers beneficial effects on insomnia and circadian sleep disorders induced by psychophysiological stress.

Keywords: Lactobacillus brevis; circadian rhythm; sleep; stress; wheel-running activity.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus brevis SBC8803Improved Circadian RhythmBeneficial
Moderate
Lactobacillus brevis SBC8803Improved NREM Sleep IntensityBeneficial
Large
Lactobacillus brevis SBC8803Increased WakefulnessBeneficial
Large
Lactobacillus brevis SBC8803Reduced InsomniaBeneficial
Large

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