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Dietary Heat-Killed Lactobacillus brevis SBC8803 Attenuates Chronic Sleep Disorders Induced by Psychophysiological Stress in Mice.

  • 2019-04-30
  • Journal of Nutritional Science and Vitaminology 65(2)
    • Sayaka Higo-Yamamoto
    • Saori Yamamoto
    • K. Miyazaki
    • Y. Nakakita
    • H. Kaneda
    • Y. Takata
    • Takeshi Nakamura
    • K. Oishi


We previously reported that dietary heat-killed Lactobacillus brevis SBC8803 affects sleep in mice and humans. The present study examined whether SBC8803 improves psychophysiological stress-induced chronic sleep disorders (CSD) using a mouse model characterized by disrupted circadian rhythms of wheel-running activity and sleep-wake cycles. Mice were fed with a diet supplemented with 0.5% heat-killed SBC8803 for 6 wk and imposed stress-induced CSD for last 2 wk. Dietary SBC8803 suppressed the reduction in wheel-running activity induced by CSD. Electroencephalography (EEG) revealed that SBC8803 significantly restored wakefulness and increased non-rapid eye movement (NREM) sleep during the second half of the active phase during CSD. The CSD-induced reduction in EEG slow wave activity, a marker of NREM sleep intensity, during the beginning of the inactive phase was significantly improved by SBC8803 supplementation. These findings suggest that dietary heat-killed SBC8803 confers beneficial effects on insomnia and circadian sleep disorders induced by psychophysiological stress.

Keywords: Lactobacillus brevis; circadian rhythm; sleep; stress; wheel-running activity.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus brevis SBC8803Improved Circadian RhythmBeneficial
Lactobacillus brevis SBC8803Improved NREM Sleep IntensityBeneficial
Lactobacillus brevis SBC8803Increased WakefulnessBeneficial
Lactobacillus brevis SBC8803Reduced InsomniaBeneficial

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