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Abstract

This study examines the effect of dietary supplementation with Lactobacillus acidophilus (LA) on the cholesterol levels, immune response, and productive performance of laying hens. A total of 216, 40-week-old, commercial Hy-Line brown chicken layers were randomly assigned into four treatment groups (18 birds × three replicates per group) and fed diet supplemented with 0 (control), 1 × 109, 21 × 109, and 31 × 109 colony forming units (CFUs) of Lactobacillus acidophilus (LA) per kg of feed for six consecutive weeks. Results show that plasma triglycerides, low-density lipoprotein (LDL) and total cholesterols became lesser, while high-density lipoprotein (HDL) cholesterol became higher in LA-supplemented groups compared to the control. In addition, a significant reduction occurred in the liver and egg yolk cholesterol by LA supplementation. Moreover, the immunological parameters including antibody titer against sheep red blood cells (SRBCs), phytohemagglutinin (PHA)-wattle swelling test, and T- & B-lymphocyte proliferation were enhanced in laying hens supplemented with LA compared to the control hens. While the heterophil to lymphocyte (H/L) ratio decreased with LA supplementation, indicating low stress conditions in the treated hens. These positive effects for LA were further reflected on the productive performance of laying hens and improved egg production, egg weight, egg mass, and feed efficiency. Our findings indicate that LA probiotic could be recommended in laying hens' diets for lowering egg yolk cholesterol with positive impacts on health and performance.

Keywords: Lactobacillus acidophilus; chickens; cholesterol contents; immunological parameters; laying performance.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus acidophilusImproved Immune ResponseBeneficial
Large
Lactobacillus acidophilusImproved Productive PerformanceBeneficial
Moderate
Lactobacillus acidophilusReduced Stress LevelsBeneficial
Moderate
Lactobacillus acidophilus LA-02Improved Immune ResponseBeneficial
Large
Lactobacillus acidophilus LA-02Increased HDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus acidophilus LA-02Reduced Stress Hormone LevelsBeneficial
Moderate
Lactobacillus acidophilus LA1Improved Immune ResponseBeneficial
Large
Lactobacillus acidophilus LA1Improved Productive PerformanceBeneficial
Moderate
Lactobacillus acidophilus LA1Increased HDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus acidophilus LA1Reduced Stress LevelsBeneficial
Moderate
Lactobacillus acidophilus La-14Enhanced Immune ResponseBeneficial
Moderate
Lactobacillus acidophilus La-14Enhanced T- and B-Lymphocyte ProliferationBeneficial
Moderate
Lactobacillus acidophilus La-14Improved Egg WeightBeneficial
Large
Lactobacillus acidophilus La-14Improved Feed EfficiencyBeneficial
Large
Lactobacillus acidophilus La-14Increased Antibody TiterBeneficial
Moderate
Lactobacillus acidophilus La-14Increased Egg MassBeneficial
Large
Lactobacillus acidophilus La-14Increased Egg ProductionBeneficial
Large
Lactobacillus acidophilus La-14Increased HDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus acidophilus La-14Reduced Heterophil-to-Lymphocyte RatioBeneficial
Moderate
Lactobacillus acidophilus La-14Reduced LDL CholesterolBeneficial
Moderate
Lactobacillus acidophilus La-14Reduced Liver Cholesterol LevelsBeneficial
Moderate
Lactobacillus acidophilus La-14Reduced Plasma TriglyceridesBeneficial
Moderate
Lactobacillus acidophilus La-14Reduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus acidophilus La-14Reduced Yolk Cholesterol ContentBeneficial
Moderate
Lactobacillus acidophilus LA-5Improved Feed EfficiencyBeneficial
Large
Lactobacillus acidophilus LA-5Improved Immune ResponseBeneficial
Large
Lactobacillus acidophilus LA-5Improved Productive PerformanceBeneficial
Moderate
Lactobacillus acidophilus LA-5Increased HDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus acidophilus LA-5Reduced Stress LevelsBeneficial
Moderate

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