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Dietary Vitamin K Intake and Fracture Risk: A Systematic Review and Dose-Response Meta-Analysis on the Interplay with Vitamin D.

  • 2025-09-09
  • Current rheumatology reviews 21
    • Mohammad Mehdi Lari Haghighat
    • Babak Haghpanah
    • Alireza Milajerdi

Study Design

Type
Meta-Analysis
Sample size
n = 776
Population
six studies encompassing 93,776 participants and 1394 instances of fractures
Methods
comprehensive search in PubMed and EMBASE databases from January 1966 to July 2025; GRADE assessment

Background

Fractures are a significant global health issue, particularly among older adults, and are associated with substantial morbidity and mortality. While several risk factors are well-established, the role of dietary vitamin K in fracture prevention remains unclear, with existing epidemiological studies yielding inconsistent results.

Objective

This meta-analysis aimed to comprehensively evaluate the association between dietary vitamin K intake and the risk of fractures, including a dose-response analysis to explore potential non-linear relationships.

Methods

A comprehensive search was conducted in the PubMed and EMBASE databases, covering the period from January 1966 to July 2025. The certainty of the evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) framework.

Results

A total of six studies encompassing 93,776 participants and 1394 instances of fractures were analyzed. We found a trend towards a decreased risk of overall fractures with increased vitamin K consumption, with a risk ratio of 0.83 (95% CI, 0.68-1.01). Similarly, vitamin K intake showed a trend toward a reduced risk of hip fractures (risk ratio: 0.76, 95% CI: 0.56-1.02; I2 = 43.91%). Furthermore, the risk of overall fractures decreased with dietary vitamin K consumption up to 120 μg/day.

Conclusions

Our meta-analysis suggests that dietary vitamin K intake may have a protective effect against fractures. We observed a U-shaped association between fracture risk and vitamin K intake at recommended dietary allowance (RDA) levels. Further studies in diverse populations, examining different forms of vitamin K and their relation to fracture risk at various skeletal sites, are warranted.

Systematic review registration

PROSPERO 1016592.

Research Insights

  • Vitamin K→Reduced Fracture Risk

    We found a trend towards a decreased risk of overall fractures with increased vitamin K consumption, with a risk ratio of 0.83 (95% CI, 0.68-1.01).

    Effect
    Neutral
    Effect size
    Small
  • Vitamin K→Reduced Hip Fracture Risk

    Similarly, vitamin K intake showed a trend toward a reduced risk of hip fractures (risk ratio: 0.76, 95% CI: 0.56-1.02; I2 = 43.91%).

    Effect
    Neutral
    Effect size
    Small
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