Discovery of dietary beneficial compounds for healthy aging: From worm to human.
- 2025-10
- Food research international (Ottawa, Ont.) 218
- Xianjiang Ye
- Hao Wang
- Yuxuan Han
- Xing Fu
- Jiuliang Zhang
- Tao Zhang
- PubMed: 40790639
- DOI: 10.1016/j.foodres.2025.116916
Study Design
- Type
- Review
Aging is marked by a decline in physiological functions and an increased susceptibility to neurodegenerative disorders. As the aging population rapidly expands, optimizing dietary nutrients has become a crucial strategy for promoting healthy aging. Bioactive compounds, abundant in dietary sources, offer a promising solution to reduce the risks of age-related diseases. Focusing on Caenorhabditis elegans (C. elegans) models and clinical research, this review synthesizes recent advances in understanding the anti-aging effects and mechanistic insights of dietary bioactive compounds, such as fisetin, quercetin, epicatechin, nobiletin, naringenin, nomilin, resveratrol, ergothioneine, coumarin, sesamin and oleic acid. By exploring the metabolic similarities between C. elegans and humans, we propose C. elegans model serves as a pioneer for discovering dietary anti-aging compounds, which enables high-throughput screening. This up-to-date summary of the anti-aging effect of dietary bioactive compounds has demonstrated powerful potential for promoting healthy aging in the human population. Future research should focus on elucidating the bioavailability, metabolic interactions, and synergistic effects of these bioactive compounds to facilitate their translation into effective dietary interventions.