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Does Streptococcus Salivarius Strain M18 Assumption Make Black Stains Disappear in Children?

  • 2020-04-03
  • Oral health & preventive dentistry 18(2)
    • Elena Bardellini
    • Francesca Amadori
    • Emanuela Gobbi
    • Anna Ferri
    • Giulio Conti
    • Alessandra Majorana

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 29
Population
58 children (aged 4-10 years) with black stains
Methods
Randomized controlled study; children randomly divided into two groups: group A receiving Streptococcus salivarius M18 once a day for 3 months, group B no treatment; professional removal of black stains before study start
Blinding
Open-label
Duration
3 months

Purpose

This randomised controlled study evaluated the effectiveness of an oral probiotic, Streptococcus salivarius M18 (SsM18), in children with black stains (BSs) in order to counteract their reformation.

Materials and methods

Fifty-eight children (aged 4-10 years) presenting with BSs were enrolled. They were randomly divided into two groups: group A (n = 29) included children who were given the test product containing SsM18 once a day for 3 months; group B (n = 29) included children who did not receive any treatment. Before beginning the study, all the children underwent professional removal of BSs. The assessment of BSs was done after 3 months (T1) and after 6 months (T2).

Results

Four patients (1 belonging to group A and 3 to group B) were excluded from the study because they started antibiotic therapy. After 3 months (T1), BSs were detected in 6 of the 28 children (21.2%) from group A and in 13 out of the 26 (50%) children from group B (p < 0.05). After 6 months (T2), BSs were detected in 9 out of the 28 (32.1%) children from group A and in 14 of the 26 (53.8%) children from group B (p > 0.05).

Conclusions

BSs formation in children could be prevented by administering S. salivarius M18.

Research Insights

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