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Abstract

Lactobacillus delbrueckii ssp. delbrueckii (AS13B), isolated from the gut of adult Dicentrarchus labrax, was administered live to developing sea bass using rotifers and Artemia as live carriers. Immune-related gene transcripts were quantified in post-larvae at day 70 post-hatch (ph) and histology, electron microscopy and immunocytochemistry of the intestinal tissue were performed at day 74 ph. Since the probiotic was orally administered the studies were focused on intestinal immunity. In treated fish gut integrity was unaffected, while the density of T-cells and acidophilic granulocytes in the intestinal mucosa was significantly higher than in controls. Probiotic-induced increases in intestinal T-cells and total body TcR-beta transcripts are first reported in fish. Significantly lower IL-1beta transcripts and a trend towards lower IL-10, Cox-2 and TGF-beta transcription were found in the treated group. Evidence is provided that early feeding with probiotic-supplemented diet stimulated the larval gut immune system and lowered transcription of key pro-inflammatory genes.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus delbrueckiiImproved Gut Immune FunctionBeneficial
Moderate
Lactobacillus delbrueckiiReduced Inflammation LevelsBeneficial
Moderate
Lactobacillus delbrueckii VPro 315Enhanced Gut Immune FunctionBeneficial
Large
Lactobacillus delbrueckii VPro 315Increased Intestinal T-Cell CountBeneficial
Large
Lactobacillus delbrueckii VPro 315Reduced Pro-inflammatory Gene TranscriptionBeneficial
Moderate

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