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Echinacea can help with Azithromycin in prevention of recurrent tonsillitis in children.

  • 2020-07
  • American journal of otolaryngology 41(4)
    • Osama G Abdel-Naby Awad

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 100
Population
children with recurrent tonsillitis
Methods
prospective comparative study; three groups: no prophylaxis, AZT alone (60 mg/kg prophylactic dose divided as 10 mg/kg/day over 6 consecutive days every month for 6 months), AZT plus Echinacea (dose of 5 ml oral suspension; 3 times daily for 10 consecutive days every month for 6 months)
Blinding
Open-label
Duration
6 consecutive months
Funding
Unclear
  • Large Human Trial

Purpose

Recurrent tonsillitis in children is a common disease affecting children quality of life and extends to their families. The aim of this study was to assess the effect of combined use of oral Azithromycin (AZT) plus Echinacea compared to exclusive use of AZT in children with recurrent tonsillitis.

Material and methods

A prospective comparative study including three groups of children with recurrent tonsillitis. Group 1: (100 patients) had no prophylactic treatment. Group 2 (100 patients) received [60 mg/kg] prophylactic dose of AZT divided as (10 mg/kg/day) over 6 consecutive days every month for 6 consecutive months. Group 3 (100 patients) received AZT as in group 2 plus commercially available Echinacea in a dose of 5 ml oral suspension; 3 times daily for 10 consecutive days every month for 6 consecutive months. Number of tonsillitis attacks and severity of tonsillitis symptoms were assessed and compared in different groups.

Results

Group 2 and group 3 had significant less number of tonsillitis attacks and severity of assessed symptoms during 6 months of prophylactic treatment with significant better results in group 3 (i.e. AZT plus Echinacea) compared to group 2 (I.e. AZT alone). However; there was no significant difference in patients with any prophylaxis.

Conclusion

The combined use of Echinacea with Azithromycin produced favorable outcome than Azithromycin alone in pediatric patients with recurrent tonsillitis.

Research Insights

  • Echinacea→Reduced Tonsillitis Attack Frequency

    Group 2 and group 3 had significant less number of tonsillitis attacks and severity of assessed symptoms during 6 months of prophylactic treatment with significant better results in group 3 (i.e. AZT plus Echinacea) compared to group 2 (I.e. AZT alone)

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    5 ml oral suspension; 3 times daily for 10 consecutive days every month
  • Echinacea→Reduced Tonsillitis Severity

    Group 2 and group 3 had significant less number of tonsillitis attacks and severity of assessed symptoms during 6 months of prophylactic treatment with significant better results in group 3 (i.e. AZT plus Echinacea) compared to group 2 (I.e. AZT alone)

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    5 ml oral suspension; 3 times daily for 10 consecutive days every month
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