Effect of administration of bifidobacteria on intestinal microbiota in low-birth-weight infants and transition of administered bifidobacteria: a comparison between one-species and three-species administration.
- 2013-10
- Anaerobe 23
- S. Ishizeki
- Masaoki Sugita
- M. Takata
- T. Yaeshima
- PubMed: 23988359
- DOI: 10.1016/j.anaerobe.2013.08.002
Abstract
The effects of administration of bifidobacteria on the intestinal microbiota in low-birth-weight infants, and the transition of each strain of administered bifidobacteria were investigated. A single strain of Bifidobacterium breve M-16V (5 × 10(8); one-species group) or a mixture of three species composed of B. breve M-16V, Bifidobacterium longum subsp. infantis M-63 and B. longum subsp. longum BB536 (5 × 10(8) of each strain; three-species group) were administered daily for 6 weeks. Bifidobacterial administration significantly increased the detection rates and cell numbers of bifidobacteria in the feces (weeks 1-6). The proportion of bifidobacteria was significantly higher in the one-species group at weeks 1-4, and in the three-species group at weeks 1-6 compared with the control group. Furthermore, the proportion of bifidobacteria in the three-species group was significantly higher than that in the one-species group at weeks 1 and 6. The proportion of infants with bifidobacteria-predominant microbiota was significantly higher in the three-species group than in the control group during the test period. The detection rates of Clostridium were lower in the bifidobacteria-administered groups. The proportions of Enterobacteriaceae were significantly lower in the three-species group compared to the other groups (weeks 4 and 6). Among the three strains administered, B. breve M-16V and Bifidobacterium infantis M-63 were detected in 85% or more of the infants during the administration period, while B. longum BB536 was detected in 40% or less. Compared with administration of one species, administration of three species of bifidobacteria resulted in earlier formation of a bifidobacteria-predominant fecal microbiota and maintenance of this microbiota.
Keywords: Bifidobacteria; Intestinal microbiota; Premature infant.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bifidobacterium breve M-16V | Increased Bifidobacterial Levels | Beneficial | Large |
| Bifidobacterium breve M-16V | Reduced Detection Rates of Clostridium | Beneficial | Moderate |
| Bifidobacterium infantis | Formation of Bifidobacteria Predominant Microbiota | Beneficial | Large |
| Bifidobacterium infantis | Reduced Detection Rates of Clostridium | Beneficial | Moderate |
| Bifidobacterium infantis | Reduced Enterobacteriaceae Counts | Beneficial | Large |
| Bifidobacterium infantis M-63 | Increased Proportion of Bifidobacteria in Gut Microbiota | Beneficial | Large |
| Bifidobacterium infantis M-63 | Reduced Detection Rates of Clostridium | Beneficial | Moderate |
| Bifidobacterium infantis M-63 | Reduced Enterobacteriaceae Counts | Beneficial | Large |
| Bifidobacterium longum subsp. infantis | Increased Proportion of Bifidobacteria in Gut Microbiota | Beneficial | Large |
| Bifidobacterium longum subsp. infantis | Reduced Enterobacteriaceae Counts | Beneficial | Large |
| Bifidobacterium longum subsp. infantis M-63 | Formation of Bifidobacteria Predominant Microbiota | Beneficial | Large |
| Bifidobacterium longum subsp. infantis M-63 | Increased Detection of Bifidobacteria | Beneficial | Large |
| Bifidobacterium longum subsp. infantis M-63 | Increased Proportion of Bifidobacteria in Gut Microbiota | Beneficial | Large |
| Bifidobacterium longum subsp. infantis M-63 | Reduced Enterobacteriaceae Counts | Beneficial | Large |