Effect of administration of Lactobacillus gasseri on serum lipids and fecal steroids in hypercholesterolemic rats.
- 2000-08
- Journal of Dairy Science 83(8)
- Usman
- A. Hosono
- PubMed: 10984145
- DOI: 10.3168/JDS.S0022-0302(00)75039-9
Abstract
The effects of milk and nonfermented milks produced from Lactobacillus gasseri on serum lipids and total bile acids and fecal steroids and microflora were estimated in rats fed cholesterol-enriched diets. Lactobacilli decreased and coliforms increased in feces of the control group; however, the concentrations of fecal lactobacilli remained unchanged when rats were fed nonfermented milks. Fecal coliforms in rats receiving milk and nonfermented milk produced from L. gasseri SBT0270 increased, while rats receiving nonfermented milk produced from L. gasseri SBT0274 had lower fecal coliform count than did the control group. Only NFM-A significantly reduced serum total cholesterol and low-density lipoprotein (LDL) cholesterol, and bile acids. High-density lipoprotein (HDL) cholesterol was significantly decreased when rats were given milk and nonfermented milks. Milk and NFM-A lowered serum triglycerides levels. Milk and nonfermented milks did not affect the total neutral steroids, but higher levels of acidic steroid were detected in the feces than the control group. The results showed that the hypocholesterolemic effect of L. gasseri SBT0270 was attributed to its ability to suppress the reabsorption of bile acids into the enterohepatic circulation and to enhance the excretion of acidic steroids in feces of hypercholesterolemic rats.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus gasseri | Increased Fecal Acidic Steroid Levels | Beneficial | Small |
| Lactobacillus gasseri | Reduced HDL Cholesterol Levels | Harmful | Moderate |
| Lactobacillus gasseri | Reduced Serum Triglyceride Levels | Beneficial | Small |
| Lactobacillus gasseri BNR17 | Increased Fecal Acidic Steroid Levels | Beneficial | Small |
| Lactobacillus gasseri BNR17 | Reduced Coliform Counts | Beneficial | Moderate |
| Lactobacillus gasseri BNR17 | Reduced HDL Cholesterol Levels | Harmful | Moderate |
| Lactobacillus gasseri BNR17 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Lactobacillus gasseri BNR17 | Reduced Serum Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus gasseri BNR17 | Reduced Serum Triglyceride Levels | Beneficial | Small |
| Lactobacillus gasseri KS-13 | Elevated Fecal Acidic Steroid Levels | Beneficial | Moderate |
| Lactobacillus gasseri KS-13 | Reduced Fecal Coliform Count | Beneficial | Moderate |
| Lactobacillus gasseri KS-13 | Reduced HDL Cholesterol Levels | Harmful | Moderate |
| Lactobacillus gasseri KS-13 | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus gasseri KS-13 | Reduced Serum Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus gasseri KS-13 | Reduced Serum Triglyceride Levels | Beneficial | Small |
| Lactobacillus gasseri LAC-343 | Increased Excretion of Acidic Steroids in Feces | Beneficial | Moderate |
| Lactobacillus gasseri LAC-343 | Reduced HDL Cholesterol Levels | Harmful | Moderate |
| Lactobacillus gasseri LAC-343 | Reduced Serum Triglyceride Levels | Beneficial | Small |
| Lactobacillus gasseri LBV 150N | Increased Fecal Acidic Steroid Levels | Beneficial | Small |
| Lactobacillus gasseri LBV 150N | Reduced HDL Cholesterol Levels | Harmful | Moderate |
| Lactobacillus gasseri LBV 150N | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus gasseri LBV 150N | Reduced Serum Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus gasseri LBV 150N | Reduced Serum Triglyceride Levels | Beneficial | Small |
| Lactobacillus gasseri LG-36 | Increased Fecal Acidic Steroid Levels | Beneficial | Small |
| Lactobacillus gasseri LG-36 | Reduced HDL Cholesterol Levels | Harmful | Moderate |
| Lactobacillus gasseri LG-36 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Lactobacillus gasseri LG-36 | Reduced Serum Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus gasseri LG-36 | Reduced Serum Triglyceride Levels | Beneficial | Small |
| Lactobacillus gasseri LQ-36 | Increased Urinary Excretion of Acidic Steroids | Beneficial | Moderate |
| Lactobacillus gasseri LQ-36 | Reduced Bile Acid Reabsorption | Beneficial | Moderate |
| Lactobacillus gasseri LQ-36 | Reduced HDL Cholesterol Levels | Harmful | Moderate |
| Lactobacillus gasseri LQ-36 | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus gasseri LQ-36 | Reduced Serum Triglyceride Levels | Beneficial | Small |
| Lactobacillus gasseri LQ-36 | Reduced Total Cholesterol Levels | Beneficial | Large |
| Lactobacillus gasseri SD-5585 | Increased Excretion of Acidic Steroids in Feces | Beneficial | Moderate |
| Lactobacillus gasseri SD-5585 | Reduced Bile Acid Levels | Beneficial | Large |
| Lactobacillus gasseri SD-5585 | Reduced High-Density Lipoprotein (HDL) Cholesterol | Harmful | Small |
| Lactobacillus gasseri SD-5585 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Lactobacillus gasseri SD-5585 | Reduced Serum Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus gasseri SD-5585 | Reduced Serum Triglyceride Levels | Beneficial | Small |
| Lactobacillus gasseri UALg-05 | Increased Excretion of Acidic Steroids in Feces | Beneficial | Moderate |
| Lactobacillus gasseri UALg-05 | Reduced HDL Cholesterol Levels | Harmful | Moderate |
| Lactobacillus gasseri UALg-05 | Reduced Serum Triglyceride Levels | Beneficial | Small |