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Bacillus coagulans SNZ 1969 (B. coagulans SNZ 1969) is a spore-forming bacterium reported to be effective in attenuating constipation. However, there is no study on whether B. coagulans SNZ 1969 could improve constipation through mucin secretion and changes in intestinal hormones. To address this knowledge gap, rats were orally administrated with various treatments for four weeks. The normal control (NOR) group received saline only. There were four constipation-induced groups. The LOP group received only loperamide (LOP), a constipation-inducing agent. The BIS group received both LOP and Bisacodyl (BIS, a constipation treatment agent). The SNZ-L group received both LOP and B. coagulans SNZ 1969 at 1 × 108 CFU/day. The SNZ-H group received LOP and _B._coagulans SNZ 1969 at 1 × 1010 CFU/day. As indicators of constipation improvement, fecal pellet weight, fecal water content, gastrointestinal transit time, and intestinal motility were measured. Mucus secretion in the colon was determined by histological colon analysis and mucin-related gene expressions. Gastrointestinal (GI) hormones were also measured. SNZ-L and SNZ-H groups showed significantly increased fecal weights, fecal water contents, and intestinal motility than the LOP group. SNZ-L and SNZ-H groups also showed higher secretion of mucin in the colon and mRNA expression levels of Mucin 2 and Aquaporin 8 than the LOP group. The SNZ-H group showed significantly increased substance P but significantly decreased somatostatin and vasoactive intestinal peptide than the LOP group. The results of this study suggest that B. coagulans SNZ 1969 intake could attenuate constipation through mucin secretion and alteration of GI hormones.

Keywords: Bacillus coagulans; bowel movement; constipation; gastrointestinal hormone; mucin; probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bacillus clausii SNZ-1971Increased Bowel Movement FrequencyBeneficial
Bacillus clausii SNZ-1971Increased Intestinal GLP-1 LevelsBeneficial
Bacillus clausii SNZ-1971Increased Mucin SecretionBeneficial
Bacillus coagulans SNZ-1969Increased Bowel Movement FrequencyBeneficial
Bacillus coagulans SNZ-1969Increased Intestinal GLP-1 LevelsBeneficial
Bacillus coagulans SNZ-1969Increased Mucin SecretionBeneficial

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