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Effect of Bifidobacterium animalis ssp. lactis GCL2505 on visceral fat accumulation in healthy Japanese adults: a randomized controlled trial

  • 2016
  • Bioscience of Microbiota, Food and Health 35(4)
    • Shota Takahashi
    • D. Anzawa
    • K. Takami
    • Akihiro Ishizuka
    • Takashi Mawatari
    • Kohei Kamikado
    • Haruhi Sugimura
    • Tomohiko Nishijima

Abstract

Bifidobacterium animalis ssp. lactis GCL2505 (B. lactis GCL2505) is able to survive passage through the intestine and then proliferate, leading to an increase in the amount of gut bifidobacteria. In the present study, we evaluated the impact of B. lactis GCL2505 on abdominal visceral fat storage in overweight and mildly obese Japanese adults. This clinical study was a double-blind, randomized, placebo-controlled, parallel-group comparative trial performed for 12 weeks. Healthy Japanese subjects (N=137) with body mass indices ranging from 23 to 30 kg/m2 consumed either fermented milk containing B. lactis GCL2505 or a placebo every day, and then visceral and subcutaneous abdominal fat areas were measured by computed tomography as the primary endpoints. The number of fecal bifidobacteria was also measured. Visceral fat area, but not subcutaneous fat area, was significantly reduced from baseline at 8 and 12 weeks in the GCL2505 group, compared with the placebo group. The total number of fecal bifidobacteria was significantly increased in the GCL2505 group. These results indicate that B. lactis GCL2505 reduces abdominal visceral fat, a key factor associated with metabolic disorders. This finding suggests that this probiotic strain can potentially serve as a specific functional food to achieve visceral fat reduction in overweight or mildly obese individuals.

Keywords: Bifidobacterium; overweight; probiotics; randomized trial; visceral fat.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium animalisIncreased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium animalisReduced Visceral FatBeneficial
Moderate
Bifidobacterium animalis subsp. lactisIncreased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactisReduced Abdominal Visceral FatBeneficial
Large
Bifidobacterium animalis subsp. lactis B420Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactis B420Reduced Visceral FatBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Increased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Reduced Visceral FatBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Increased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Reduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Increased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Reduced Visceral FatBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Increased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Reduced Visceral FatBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Increased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Reduced Visceral FatBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactis VK2Reduced Abdominal Visceral FatBeneficial
Large
Bifidobacterium bifidum/lactis Bb-02Increased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Reduced Visceral FatBeneficial
Moderate
Bifidobacterium lactisIncreased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium lactisReduced Visceral FatBeneficial
Moderate
Bifidobacterium lactis B420Increased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium lactis B420Reduced Abdominal Visceral FatBeneficial
Large
Bifidobacterium lactis Bb-02Increased Fecal BifidobacteriaBeneficial
Large
Bifidobacterium lactis Bb-02Reduced Abdominal Visceral Fat AreaBeneficial
Moderate
Bifidobacterium lactis BI-04Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactis BI-04Reduced Visceral FatBeneficial
Moderate
Bifidobacterium lactis Bi-07Increased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium lactis Bi-07Reduced Abdominal Visceral Fat AreaBeneficial
Moderate
Bifidobacterium lactis Bl-04Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactis Bl-04Reduced Abdominal Visceral Fat AreaBeneficial
Moderate
Bifidobacterium lactis BL818Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactis BL818Reduced Abdominal Visceral FatBeneficial
Large
Bifidobacterium lactis BLA80Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactis BLA80Reduced Visceral FatBeneficial
Moderate
Bifidobacterium lactis BLC-1Increased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium lactis BLC-1Reduced Visceral FatBeneficial
Moderate
Bifidobacterium lactis BS01Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactis BS01Reduced Visceral FatBeneficial
Moderate
Bifidobacterium lactis DSM 15954Increased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium lactis DSM 15954Reduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium lactis HA-194Increased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium lactis HA-194Reduced Visceral FatBeneficial
Moderate
Bifidobacterium lactis HDS Bb-02Increased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium lactis HDS Bb-02Reduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium lactis ISS BifIncreased Fecal BifidobacteriaBeneficial
Large
Bifidobacterium lactis ISS BifReduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium lactis/longumIncreased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactis/longumReduced Visceral FatBeneficial
Moderate
Bifidobacterium lactis MAK16B42LIncreased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium lactis MAK16B42LReduced Visceral FatBeneficial
Moderate
Bifidobacterium lactis R101-8Increased Gut BifidobacteriaBeneficial
Moderate
Bifidobacterium lactis R101-8Reduced Abdominal Visceral Fat AreaBeneficial
Moderate
Bifidobacterium lactis SD-5219Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactis SD-5219Reduced Visceral FatBeneficial
Moderate
Bifidobacterium lactis UABla-12Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactis UABla-12Reduced Visceral FatBeneficial
Moderate

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