Skip to main content

Effect of combined bifidobacteria supplementation and resistance training on cognitive function, body composition and bowel habits of healthy elderly subjects.

  • 2018-12-07
  • Beneficial Microbes 9(6)
    • T. Inoue
    • Y. Kobayashi
    • N. Mori
    • M. Sakagawa
    • J.‐Z. Xiao
    • Toshio Moritani
    • Naoki Sakane
    • N. Nagai

Abstract

Physical exercise exerts favourable effects on brain health and quality of life of the elderly; some of these positive health effects are induced by the modulation of microbiota composition. We therefore conducted a randomised, double blind, placebo-controlled trial that assessed whether a combination of Bifidobacterium spp. supplementation and moderate resistance training improved the cognitive function and other health-related parameters in healthy elderly subjects. Over a 12-week period, 38 participants (66-78 years) underwent resistance training and were assigned to the probiotic Bifidobacterium supplementation (n=20; 1.25×1010 cfu each of Bifidobacterium longum subsp. longum BB536, B. longum subsp. infantis M-63, Bifidobacterium breve M-16V and B. breve B-3) or the placebo (n=18) group. At baseline and at 12 weeks, we assessed the cognitive function, using the Japanese version of the Montreal Cognitive Assessment instrument (MoCA-J); modified flanker task scores; depression-anxiety scores; body composition; and bowel habits. At 12 weeks, the MoCA-J scores showed a significant increase in both the groups, while the flanker task scores of the probiotic group increased more significantly than those of the placebo group (0.35±0.9 vs -0.29±1.1, P=0.056). Only the probiotic group showed a significant decrease in the depression-anxiety scores (5.2±6.3 to 3.4±5.5, P=0.012) and body mass index (24.0±2.8 to 23.5±2.8 kg/m2, P<0.001), with a significant increase in the defecation frequency (5.3±2.3 to 6.4±2.3 times/5 days, P=0.023) at 12 weeks. Thus, in healthy elderly subjects, combined probiotic bifidobacteria supplementation and moderate resistance training may improve the mental condition, body weight and bowel movement frequency.

Keywords: body composition; bowel habits; brain health; probiotics; resistance training.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
BifidobacteriumImproved Bowel Movement FrequencyBeneficial
Small
BifidobacteriumImproved Cognitive FunctionBeneficial
Small
BifidobacteriumReduced Body Mass IndexBeneficial
Moderate
BifidobacteriumReduced Depression and Anxiety ScoresBeneficial
Moderate
Bifidobacterium breve M-16VImproved Bowel Movement FrequencyBeneficial
Small
Bifidobacterium breve M-16VImproved Cognitive FunctionBeneficial
Small
Bifidobacterium breve M-16VReduced Body Mass IndexBeneficial
Moderate
Bifidobacterium breve M-16VReduced Depression and Anxiety ScoresBeneficial
Moderate
Bifidobacterium longum BB536Improved Bowel Movement FrequencyBeneficial
Small
Bifidobacterium longum BB536Improved Cognitive FunctionBeneficial
Small
Bifidobacterium longum BB536Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium longum BB536Reduced Depression and Anxiety ScoresBeneficial
Moderate
Bifidobacterium longum subsp. longumImproved Bowel Movement FrequencyBeneficial
Small
Bifidobacterium longum subsp. longumImproved Cognitive FunctionBeneficial
Small
Bifidobacterium longum subsp. longumReduced Anxiety ScoresBeneficial
Moderate
Bifidobacterium longum subsp. longumReduced Body Mass IndexBeneficial
Moderate

Pillser helps you make informed health decisions by providing comprehensive, unbiased information about supplements. This includes detailed research on supplement ingredients, their benefits, potential risks, and their overall efficacy. You can contribute by sharing your feedback and suggestions.

Send us an email at support@pillser.com.