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Abstract

Bifidobacterium animalis subsp. lactis GCL2505 has been shown to have several positive health effects, including improved defecation frequency and reduced visceral fat. It is known that combined intake of GCL2505 and inulin increases the total number of bifidobacteria compared with ingestion of GCL2505 alone. This randomized, double-blind, placebo-controlled, parallel-group study was conducted to confirm that consumption of GCL2505 and inulin reduces abdominal fat (n = 120). Participants consumed a test beverage containing 1 × 1010 colony-forming units of GCL2505 per 100 g and 2.0 g of inulin per 100 g for 12 weeks. A change in the visceral fat area (VFA) was set as the primary endpoint. There were significant reductions in VFA and total fat area. The intervention significantly increased the total number of bifidobacteria and affected the levels of several lipid markers. Regression analysis of bifidobacteria and measured parameters showed that total bifidobacteria correlated with VFA and body mass index (BMI), while endogenous bifidobacteria and Bifidobacterium animalis subsp. lactis correlated only with BMI, suggesting that increases in both contributed to the decrease in VFA. These results suggest that combined intake of GCL2505 and inulin improves the intestinal environment and reduces abdominal fat in association with the SCFA-mediated pathway.

Keywords: Bifidobacterium animalis subsp. lactis; abdominal fat; gut microbacteria; inulin; overweight; synbiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium lactis VK2Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis VK2Improved Intestinal HealthBeneficial
Large
Bifidobacterium lactis VK2Improved Lipid LevelsBeneficial
Moderate
Bifidobacterium lactis VK2Increased Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactis VK2Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis VK2Reduced Visceral FatBeneficial
Large

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