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Effect of Garcinia cambogia supplement on obesity indices: A systematic review and dose-response meta-analysis.

  • 2020-08
  • Complementary therapies in medicine 52
    • Mahdieh Golzarand
    • Mahsa Omidian
    • Karamollah Toolabi

Study Design

Type
Meta-Analysis
Sample size
n = 530
Population
530 subjects from eight trials
Methods
Systematic review and dose-response meta-analysis of RCTs; databases searched up to 1 January 2020

Objective

Several trials have examined the effect of Garcinia cambogia supplement on the weight and body composition, but their results are conflicting. This systematic review and dose-response meta-analysis was designed to determine the effect of Garcinia cambogia supplement on the obesity indices in human randomized controlled trials (RCTs).

Methods

PubMed/Medline, Scopus, Cochrane library, and Web of Science databases were searched up to 1th January, 2020, to screen relevant trials. The mean changes in the weight, body mass index (BMI), percentage of fat mass (PFM), and waist circumference (WC) from the baseline were used to conduct the present dose response meta-analysis.

Results

In the current study, eight trials (including 530 subjects) were included. Garcinia cambogia supplement significantly reduced the weight by -1.34 kg (95% CI: -2.62 to -0.07, P = 0.03), BMI by -0.99 kg/m2 (95% CI: -1.48 to -0.49, P < 0.001), PFM by -0.42% (95% CI: -0.77 to -0.06, P = 0.02), and WC by -4.16 cm (95% CI: -7.83 to -0.49, P = 0.02) compared with the placebo group. Dose-response analysis revealed that there is a nonlinear association between Garcinia cambogia dosage and changes in the body weight (Pnonlinearity = 0.04) and BMI (Pnonlinearity < 0.001) not PFM (Pnonlinearity = 0.68). There was no publication bias among the studies.

Conclusion

Our results suggested that Garcinia cambogia supplement had a significant effect on the body weight, BMI, PFA, and WC as compared with the placebo.

Research Insights

  • Garcinia→Reduced Body Mass Index

    Garcinia cambogia supplement significantly reduced the BMI by -0.99 kg/m² (95% CI: -1.48 to -0.49, P < 0.001).

    Effect
    Beneficial
    Effect size
    Moderate
  • Garcinia→Reduced Body Weight

    Garcinia cambogia supplement significantly reduced the weight by -1.34 kg (95% CI: -2.62 to -0.07, P = 0.03).

    Effect
    Beneficial
    Effect size
    Small
  • Garcinia→Reduced Percentage of Fat Mass

    Garcinia cambogia supplement significantly reduced the PFM by -0.42% (95% CI: -0.77 to -0.06, P = 0.02).

    Effect
    Beneficial
    Effect size
    Small
  • Garcinia→Reduced Waist Circumference

    Garcinia cambogia supplement significantly reduced the WC by -4.16 cm (95% CI: -7.83 to -0.49, P = 0.02).

    Effect
    Beneficial
    Effect size
    Moderate
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