Effect of giving probiotic supplement Lactobacillus acidophilus La-14 as an immunomodulator to maintain a respiratory system in Mus musculus.

2021-06-01
Iranian journal of microbiology 13(3)

PubMed: 34540177
DOI: 10.18502/ijm.v13i3.6401

Study Design

Population: mice Mus musculus male DDY strain aged 1-2 months
Methods: Probiotic supplement Lactobacillus acidophilus La-14 with a viability of 1 × 10^8 CFU/ml and vitamin C were administered; lung histology preparations were analyzed descriptively and statistically through the Chi square test while the data on the number of lymphocytes were analyzed descriptively

Background and objectives

In 2020 the whole world is experiencing a pandemic condition due to infection with the SARS-CoV-2 virus which can cause the COVID-19 disease. This condition results in "Panic Buying", because everyone tries to avoid the spread and transmission of the COVID-19 disease by doing various ways, one of which is by taking additional supplements such as vitamin C and probiotic supplements.

Materials and methods

The materials used were mice Mus musculus male DDY strain aged 1-2 months. Probiotic supplement Lactobacillus acidophilus La-14 with a viability of 1 × 10⁸ CFU/ml. with a weight of 0.16 grams dissolved in 0.25 ml 0.9% NaCl. Vitamin C used is a commercial vitamin C tablet, weighing 0.06 grams in 0.25 ml 0.9% NaCl. Meanwhile, the feed for mice (Mus musculus) is a complete feed from Pokphand with the code BR1 CP511B. Lung histology preparations data were analysed descriptively and statistically through the test Chi square while the data on the number of lymphocytes were analysed descriptively.

Results

The histological observations of lungs of Mus musculus showed that in the treatment of ML, MV, and MKA test was carried out chi square ratio between the groups that did not have lymphocyte infiltration and those that had lymphocyte infiltration showed a significant difference (p <0.05). Meanwhile, the results of the lymphocyte count showed that ML and MV treatment was higher than that of MK treatment.

Conclusion

It is suggested that the administration of probiotics can stimulate and modulate the respiratory immune system.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Lactobacillus acidophilus La-14	—	Improved Respiratory Innate Immune Response	Beneficial	Small	View source It is suggested that the administration of probiotics can stimulate and modulate the respiratory immune system.