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Effect of ingesting yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on influenza virus-bound salivary IgA in elderly residents of nursing homes: a randomized controlled trial

  • 2019-05-16
  • Acta Odontologica Scandinavica 77(7)
    • Yuko Yamamoto
    • J. Saruta
    • Toru Takahashi
    • M. To
    • Tomoko Shimizu
    • Takashi Hayashi
    • T. Morozumi
    • N. Kubota
    • Yohei Kamata
    • Seiya Makino
    • H. Kano
    • Jun Hemmi
    • Y. Asami
    • T. Nagai
    • K. Misawa
    • Sachiko Kato
    • K. Tsukinoki

Abstract

Objective: The purpose of this study was to clarify the influence of consuming yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 (1073R-1-yogurt) on influenza virus-bound salivary immunoglobulin A (IgA) levels, in the elderly residents of nursing homes. Methods: A double-blind, parallel-group, randomized controlled trial was conducted with 96 elderly volunteers residing in 2 nursing homes. During the trial, participants consumed 100 g of 1073R-1-yogurt every morning for 12 weeks, whereas the control participants consumed yogurt fermented with a different Lactobacillus strain (control yogurt). Saliva was collected before the trial and after 4, 8 and 12 weeks of yogurt ingestion. Results: Our data indicated that consumption of 1073R-1-yogurt affected influenza A virus subtype H3N2-bound IgA levels in saliva (p = .001). In addition, saliva flow rate and total IgA levels increased in response to the yogurt intake period in both the 1073R-1 and control yogurt groups (p = .04). Conclusions: Our study suggests that continuous daily ingestion of 1073R-1-yogurt may help prevent infection with influenza A virus subtype H3N2 in elderly subjects with weakened immunity, by increasing the production of influenza A virus subtype of H3N2-bound salivary IgA.

Keywords: IgA; Saliva; elderly population; influenza; yogurt.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus bulgaricusIncreased Salivary IgA Levels for Influenza A Virus H3N2Beneficial
Large
Lactobacillus bulgaricus LB42Increased Salivary Influenza Virus-Bound IgABeneficial
Large
Lactobacillus bulgaricus Lb-87Increased Saliva ProductionBeneficial
Small
Lactobacillus bulgaricus Lb-87Increased Salivary IgA Levels for Influenza A Virus H3N2Beneficial
Large
Lactobacillus bulgaricus Lb-87Increased Salivary sIgA LevelsBeneficial
Small
Lactobacillus bulgaricus SD-6833Increased Saliva ProductionBeneficial
Small
Lactobacillus bulgaricus SD-6833Increased Salivary IgA Levels for Influenza A Virus H3N2Beneficial
Large
Lactobacillus bulgaricus SD-6833Increased Total Immunoglobulin A (IgA) LevelsBeneficial
Moderate
Lactobacillus delbrueckiiIncreased Saliva ProductionBeneficial
Small
Lactobacillus delbrueckiiIncreased Salivary IgA LevelsBeneficial
Moderate
Lactobacillus delbrueckiiIncreased Salivary IgA Levels for Influenza A Virus H3N2Beneficial
Large
Lactobacillus delbrueckii VPro 315Increased Salivary IgA Levels for Influenza A Virus H3N2Beneficial
Large

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