Effect of Lactobacillus acidophilus KFRI342 on the development of chemically induced precancerous growths in the rat colon.
- 2012-03-01
- Journal of Medical Microbiology 61(3)
- Jin-Hee Chang
- Y. Shim
- S. Cha
- M. Reaney
- K. Chee
- PubMed: 22034161
- DOI: 10.1099/jmm.0.035154-0
Abstract
Lactobacillus acidophilus KFRI342, isolated from the Korean traditional food kimchi, was investigated for its suitability as a dietary probiotic. The effects of L. acidophilus KFRI342 on the development of chemically induced (1,2-dimethylhydrazine; DMH) precancerous cytological changes of the colon were investigated in rats. Forty-five male F344 rats were randomly divided into three dietary groups. The control group received a high-fat diet (HF), a second group received a high-fat diet containing the carcinogen (HFC), and a final group received a high-fat diet containing the carcinogen and L. acidophilus KFRI342 (HFCL). L. acidophilus KFRI342 was administered orally three times per week at 2×10(9) c.f.u. ml(-1). L. acidophilus KFRI342 treatments decreased the number of Escherichia coli in faecal samples, the enzyme activities of β-glucuronidase and β-glucosidase, and plasma triglyceride concentration compared to the HF and HFC treatments (P<0.05). L. acidophilus KFRI342 consumption also decreased the ratio of aberrant crypts to aberrant crypt foci incidence and the number of aberrant crypts in HFCL rats. Therefore, L. acidophilus showed potential probiotic activity as an inhibitor of DMH-induced symptoms in live rats. Our in vivo studies indicate that L. acidophilus from kimchi may be suitable as a probiotic for human use.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus acidophilus | Reduced Aberrant Crypts | Beneficial | Large |
| Lactobacillus acidophilus | Reduced Beta-Glucuronidase Activity | Beneficial | Moderate |
| Lactobacillus acidophilus | Reduced Fecal E. coli Populations | Beneficial | Moderate |
| Lactobacillus acidophilus | Reduced Plasma Triglycerides | Beneficial | Moderate |
| Lactobacillus acidophilus | Reduced β-Glucosidase Enzyme Activity | Beneficial | Moderate |
| Lactobacillus acidophilus HA-122 | Reduced Aberrant Crypts | Beneficial | Large |
| Lactobacillus acidophilus HA-122 | Reduced Fecal Escherichia coli Count | Beneficial | Moderate |
| Lactobacillus acidophilus HA-122 | Reduced Incidence of Aberrant Crypts Relative to Aberrant Crypt Foci | Beneficial | Moderate |
| Lactobacillus acidophilus HA-122 | Reduced Plasma Triglycerides | Beneficial | Moderate |
| Lactobacillus acidophilus MAK32L61A | Reduced Aberrant Crypt Foci | Beneficial | Large |
| Lactobacillus acidophilus MAK32L61A | Reduced Aberrant Crypt Foci Incidence | Beneficial | Large |
| Lactobacillus acidophilus MAK32L61A | Reduced E. coli Levels | Beneficial | Moderate |
| Lactobacillus acidophilus MAK32L61A | Reduced Plasma Triglycerides | Beneficial | Moderate |
| Lactobacillus acidophilus R0418 | Reduced Fecal Escherichia coli Count | Beneficial | Moderate |
| Lactobacillus acidophilus R0418 | Reduced Incidence of Aberrant Crypts | Beneficial | Large |
| Lactobacillus acidophilus R0418 | Reduced Plasma Triglycerides | Beneficial | Moderate |
| Lactobacillus acidophilus SD-5212 | Reduced Aberrant Crypts | Beneficial | Large |
| Lactobacillus acidophilus SD-5212 | Reduced E. coli Levels | Beneficial | Moderate |
| Lactobacillus acidophilus SD-5212 | Reduced Incidence of Aberrant Crypts Relative to Aberrant Crypt Foci | Beneficial | Moderate |
| Lactobacillus acidophilus SD-5212 | Reduced Plasma Triglycerides | Beneficial | Moderate |
| Lactobacillus acidophilus UALa01 | Reduced Aberrant Crypt Incidence | Beneficial | Moderate |
| Lactobacillus acidophilus UALa01 | Reduced Aberrant Crypt Number | Beneficial | Moderate |
| Lactobacillus acidophilus UALa01 | Reduced Escherichia Coli Levels | Beneficial | Moderate |
| Lactobacillus acidophilus UALa01 | Reduced Plasma Triglycerides | Beneficial | Moderate |