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Effect of Lactobacillus acidophilus NS1 on plasma cholesterol levels in diet-induced obese mice.

  • 2015-03
  • Journal of Dairy Science 98(3)
    • M. Song
    • S. Park
    • H. Lee
    • B. Min
    • S. Jung
    • S. Park
    • E. Kim
    • S. Oh

Abstract

We investigated the probiotic properties of Lactobacillus acidophilus NS1, such as acid resistance, bile tolerance, adherence to HT-29 cells, and cholesterol assimilation activity. In an animal study, 7-wk-old male C57BL/6 mice were fed a normal diet, a high-fat diet (HFD), or an HFD with L. acidophilus NS1 (ca. 1.0×10(8) cfu/mL) for 10 wk. Total cholesterol and low-density lipoprotein (LDL) cholesterol levels were significantly lower in mice fed an HFD with L. acidophilus NS1 than in those fed an HFD only, whereas high-density lipoprotein cholesterol levels were similar between these 2 groups. To understand the mechanism of the cholesterol-lowering effect of L. acidophilus NS1 on the HFD-mediated increase in plasma cholesterol levels, we determined mRNA levels of genes involved in cholesterol homeostasis in the liver. Expression of sterol regulatory element-binding protein 2 (Srebp2) and LDL receptor (Ldlr) in the liver was dramatically reduced in mice fed a HFD compared with those fed a normal diet. When L. acidophilus NS1 was administered orally to HFD-fed mice, an HFD-induced suppression of Srebp2 and Ldlr expression in the liver was abolished. These results suggest that the oral administration of L. acidophilus NS1 to mice fed an HFD increased the expression of Srebp2 and Ldlr in the liver, which was inhibited by high fat intake, thus leading to a decrease in plasma cholesterol levels. Lactobacillus acidophilus NS1 could be a useful probiotic microorganism for cholesterol-lowering dairy products and the improvement of hyperlipidemia and hepatic lipid metabolism.

Keywords: Lactobacillus acidophilus; cholesterol; obesity; probiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus acidophilus HA-122Increased Cholesterol Homeostasis Gene ExpressionBeneficial
Moderate
Lactobacillus acidophilus HA-122Reduced Plasma Cholesterol LevelsBeneficial
Large
Lactobacillus acidophilus LA1Increased Cholesterol Homeostasis Gene ExpressionBeneficial
Moderate
Lactobacillus acidophilus LA1Reduced Plasma Cholesterol LevelsBeneficial
Large
Lactobacillus acidophilus MAK32L61AImproved Hepatic Cholesterol HomeostasisBeneficial
Moderate
Lactobacillus acidophilus MAK32L61AReduced LDL CholesterolBeneficial
Large
Lactobacillus acidophilus MAK32L61AReduced Serum Total Cholesterol LevelsBeneficial
Large
Lactobacillus acidophilus UALa01Altered Gene Expression for Cholesterol RegulationBeneficial
Large
Lactobacillus acidophilus UALa01Reduced LDL CholesterolBeneficial
Large
Lactobacillus acidophilus UALa01Reduced Total Cholesterol LevelsBeneficial
Moderate

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