Effect of Lactobacillus gasseri BNR17 on blood glucose levels and body weight in a mouse model of type 2 diabetes.

2009-11
Journal of applied microbiology 107(5)

PubMed: 19457033
DOI: 10.1111/j.1365-2672.2009.04350.x

Study Design

Population: db/db mice
Methods: db/db mice were divided into one control group and five sample groups; the sample groups received BNR17 (10(7), 10(8), 10(9) and 10(10) CFU) or rosiglitazone (8 mg kg(-1)) orally twice a day for 12 weeks

Highly Cited

Aims

To investigate the effect of Lactobacillus gasseri BNR17 isolated from human breast milk on blood glucose and body weight in type 2 diabetic animals.

Methods and results

db/db mice were divided into one control group and five sample groups; the sample groups received BNR17 (10(7), 10(8), 10(9) and 10(10) CFU) or rosiglitazone (8 mg kg(-1)) orally twice a day for 12 weeks. BNR17 groups had a dose-dependent reduction in food, water intake and amount of excrement. Body weight loss was not seen in the BNR17 groups. Fasting and postprandial 2 h blood glucose levels were significantly lower in the BNR17 (10(10) CFU) group compared with the control group. HbA1c decreased in the BNR17 group, although it was not statistically significant. During the oral glucose tolerance test, the BNR17 groups exhibited dose-dependent improvement in glucose sensitivity.

Conclusions

Lactobacillus gasseri BNR17 has a suppressing effect on blood glucose levels and improved diabetic symptoms in db/db mice.

Significance and impact of the study

Blood glucose-lowering lactic acid bacteria are expected to be useful as a therapeutic for treating type 2 diabetes in humans.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Lactobacillus gasseri BNR17	—	Improved Glucose Tolerance	Beneficial	Moderate	View source During the oral glucose tolerance test, the BNR17 groups exhibited dose-dependent improvement in glucose sensitivity.
Lactobacillus gasseri BNR17	—	Prevention of Weight Loss	Beneficial	Small	View source Body weight loss was not seen in the BNR17 groups.
Lactobacillus gasseri BNR17	—	Reduced Blood Glucose Levels	Beneficial	Moderate	View source Fasting and postprandial 2 h blood glucose levels were significantly lower in the BNR17 (10(10) CFU) group compared with the control group.