Effect of Lactobacillus gasseri BNR17 on irritable bowel syndrome: a randomized, double-blind, placebo-controlled, dose-finding trial
- 2017-12-12
- Food Science and Biotechnology 27(3)
- J. Y. Kim
- Y. Park
- H. Lee
- M. Park
- O. Kwon
- PubMed: 30263811
- DOI: 10.1007/s10068-017-0296-7
Abstract
Lactobacillus gasseri BNR17 is a strain isolated from human breast milk. The objective of this randomized, double-blind, placebo-controlled, and preliminary dose-finding trial was to find the effective dose and evaluate the effect of Lb. gasseri BNR17 on irritable bowel syndrome (IBS) symptoms. A total of 55 volunteers aged over 20 years with body mass index over 23 kg/m2 were randomized to intake a placebo, low-dose (BNR-L, 2 × 108 CFU/day), intermediate-dose (BNR-M, 2 × 109 CFU/day), or high-dose BNR (BNR-H, 2 × 5 × 109 CFU/day) for four weeks. Questionnaire for IBS symptoms scores and Lb. gasseri BNR17 in feces were assessed at the beginning and end of the trial. Among IBS symptoms scores, abdominal pain score was significantly reduced in BNR-H group. Lb. gasseri BNR17 was detected in all intake groups except placebo. In the preliminary study, Lb. gasseri BNR17 was confirmed to have probiotic properties.
Keywords: Irritable bowel syndrome; Lactobacillus gasseri BNR17; Probiotics.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus gasseri | Reduced Abdominal Pain Severity | Beneficial | Moderate |
| Lactobacillus gasseri BNR17 | Reduced Abdominal Pain Severity | Beneficial | Moderate |
| Lactobacillus gasseri KS-13 | Reduced Abdominal Pain Severity | Beneficial | Moderate |
| Lactobacillus gasseri LAC-343 | Presence of Lactobacillus gasseri BNR17 in Feces | Neutral | Small |
| Lactobacillus gasseri LAC-343 | Reduced Abdominal Pain Severity | Beneficial | Moderate |
| Lactobacillus gasseri LBV 150N | Reduced Abdominal Pain | Beneficial | Large |
| Lactobacillus gasseri LQ-36 | Reduced Abdominal Pain Severity | Beneficial | Moderate |
| Lactobacillus gasseri SD-5585 | Presence of Lactobacillus gasseri BNR17 in Feces | Neutral | Small |
| Lactobacillus gasseri SD-5585 | Reduced Abdominal Pain | Beneficial | Large |
| Lactobacillus gasseri UALg-05 | Reduced Abdominal Pain | Beneficial | Large |
| Lactobacillus LB | Presence of Lactobacillus gasseri BNR17 in Feces | Neutral | Small |
| Lactobacillus LB | Reduced Abdominal Pain | Beneficial | Large |